Detalhe da pesquisa
1.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Nature
; 613(7945): 767-774, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36450356
2.
3.
Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit.
Bioorg Med Chem Lett
; 26(1): 174-80, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26602281
4.
Think Big, Start Small: How Nanomedicine Could Alleviate the Burden of Rare CNS Diseases.
Pharmaceuticals (Basel)
; 14(2)2021 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573213
5.
Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy.
Nat Commun
; 12(1): 3858, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34158473
6.
Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies.
Eur J Med Chem
; 215: 113275, 2021 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33618157
7.
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Elife
; 102021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33555255
8.
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
J Med Chem
; 64(18): 13873-13892, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34505767
9.
Synthesis and Pharmacology of a Novel µ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.
J Med Chem
; 63(22): 13618-13637, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33170687