Detalhe da pesquisa
1.
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature
; 575(7781): 217-223, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31666701
2.
Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations.
Acc Chem Res
; 55(20): 2892-2903, 2022 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36178208
3.
Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation.
Bioorg Med Chem Lett
; 30(21): 127499, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32858124
4.
Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.
Bioorg Med Chem Lett
; 25(4): 775-80, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25616902
5.
The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.
Bioorg Med Chem Lett
; 25(4): 834-40, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25597005
6.
The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.
Bioorg Med Chem Lett
; 25(4): 847-55, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25599837
7.
Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Bioorg Med Chem Lett
; 24(24): 5630-5634, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466188
8.
Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P1 agonists with in vivo lymphocyte-depleting activity.
Bioorg Med Chem Lett
; 22(1): 628-33, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22100314
9.
Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.
Bioorg Med Chem Lett
; 22(4): 1779-83, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22257889
10.
Quinolinone-based agonists of S1P1: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.
Bioorg Med Chem Lett
; 22(1): 527-31, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22104144
11.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820981
12.
Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
ACS Med Chem Lett
; 10(9): 1302-1308, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31531201
13.
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
J Med Chem
; 62(3): 1523-1540, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30624936
14.
EVALUATION OF STRATEGIES FOR THE SYNTHESIS OF THE GUANIDINE HEMIAMINAL PORTION OF PALAU'AMINE.
Heterocycles
; 70: 557-570, 2006 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-19079749
15.
Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.
ACS Med Chem Lett
; 7(4): 408-12, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096050
16.
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.
J Med Chem
; 59(13): 6407-30, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27285051
17.
Efficient, stereoselective synthesis of trans-2,5-disubstituted morpholines.
Org Lett
; 6(6): 1045-7, 2004 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15012096
18.
Addressing supply issues for natural products in the clinic.
Science
; 358(6360): 166-167, 2017 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29026028
19.
Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.
ACS Med Chem Lett
; 3(1): 74-8, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900374
20.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J Med Chem
; 55(11): 5188-219, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22548365