Detalhe da pesquisa
1.
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Antimicrob Agents Chemother
; 68(4): e0137323, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38380945
2.
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg Med Chem
; 27(3): 457-469, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30606676
3.
New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.
J Biol Chem
; 287(25): 21189-203, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22535962
4.
Synthesis and biological evaluation of phosphonate analogues of nevirapine.
Bioorg Med Chem Lett
; 23(5): 1493-7, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375792
5.
Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
J Med Chem
; 66(3): 1761-1777, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36652602
6.
Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase.
Antimicrob Agents Chemother
; 55(6): 2662-9, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21402840
7.
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
Antimicrob Agents Chemother
; 55(6): 2905-15, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21464257
8.
Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.
J Biol Chem
; 284(48): 33580-99, 2009 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19801648
9.
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem Lett
; 20(5): 1589-92, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20138513
10.
N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem Lett
; 20(5): 1585-8, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137928
11.
Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
ACS Med Chem Lett
; 11(4): 506-513, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292557
12.
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
ACS Med Chem Lett
; 11(3): 358-364, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184970
13.
Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.
Antivir Ther
; 14(2): 231-9, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19430098
14.
Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance.
Commun Biol
; 2: 469, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31872074
15.
Crystal structure of the bifunctional ATP sulfurylase-APS kinase from the chemolithotrophic thermophile Aquifex aeolicus.
J Mol Biol
; 365(3): 732-43, 2007 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17095009
16.
Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.
Bioorg Med Chem Lett
; 18(3): 1131-4, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083512
17.
ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
J Clin Invest
; 128(10): 4485-4500, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30024858
18.
Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1.
Eur J Med Chem
; 122: 185-195, 2016 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27371922
19.
Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.
J Med Chem
; 57(9): 3856-73, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24779514
20.
The HIV-1 reverse transcriptase M184I mutation enhances the E138K-associated resistance to rilpivirine and decreases viral fitness.
J Acquir Immune Defic Syndr
; 59(1): 47-54, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21997204