Detalhe da pesquisa
1.
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.
Xenobiotica
; 54(2): 64-74, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38197324
2.
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg Med Chem Lett
; 29(16): 2294-2301, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31307887
3.
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Drug Metab Dispos
; 44(12): 1881-1889, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27638506
4.
Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human.
Drug Metab Dispos
; 40(9): 1785-96, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22696419
5.
Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors.
Xenobiotica
; 42(5): 456-65, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22122353
6.
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Cancer Discov
; 12(1): 204-219, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34544753
7.
Preclinical absorption, distribution, metabolism, excretion, and pharmacokinetic-pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3-fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide, a novel MET kinase inhibitor.
Xenobiotica
; 41(4): 327-39, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21182395
8.
Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human.
Xenobiotica
; 41(12): 1088-99, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21838594
9.
Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.
Drug Metab Dispos
; 38(9): 1422-6, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20522663
10.
Understanding the Effect of Hydroxypropyl-ß-Cyclodextrin on Fenebrutinib Absorption in an Itraconazole-Fenebrutinib Drug-Drug Interaction Study.
Clin Pharmacol Ther
; 108(6): 1224-1232, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32535897
11.
Evaluating the Pharmacokinetics and Systemic Effects of a Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl)amino] Caprylate in Rats.
J Pharm Sci
; 109(8): 2629-2636, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32360544
12.
Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases.
Neuro Oncol
; 21(11): 1401-1411, 2019 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31173106
13.
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.
ACS Med Chem Lett
; 7(4): 351-6, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096040
14.
Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery.
Future Med Chem
; 6(18): 1995-2012, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25531965
15.
The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α.
J Med Chem
; 55(18): 8007-20, 2012 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22946614
16.
Targeting the PI3K pathway in the brain--efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier.
Clin Cancer Res
; 18(22): 6239-48, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22992516
17.
Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).
J Med Chem
; 54(8): 2592-601, 2011 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21438527
18.
Semi-automated protein binding methodology using equilibrium dialysis and a novel mixed-matrix cassette approach.
J Pharm Sci
; 99(12): 5070-8, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20821380
19.
Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513.
Eur J Pharm Sci
; 37(3-4): 463-8, 2009 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19491037