Detalhe da pesquisa
1.
Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations.
Acc Chem Res
; 55(20): 2892-2903, 2022 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36178208
2.
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Bioorg Med Chem Lett
; 80: 129084, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36423823
3.
Creating a more strategic small molecule biophysical hit characterization workflow.
SLAS Discov
; 29(4): 100159, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38723666
4.
Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer.
Cancer Discov
; 11(7): 1672-1687, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33632773
5.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820981
6.
EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus.
J Am Chem Soc
; 130(18): 6025-39, 2008 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18393503
7.
Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
J Med Chem
; 59(2): 671-86, 2016 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26700752
8.
Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
J Med Chem
; 56(3): 1023-40, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23302067
9.
Identification of novel rapamycin derivatives as low-level impurities in active pharmaceutical ingredients.
J Antibiot (Tokyo)
; 64(9): 649-54, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21792211
10.
Protein binding to lanthanide(III) complexes can reduce the water exchange rate at the lanthanide.
Inorg Chem
; 46(9): 3576-84, 2007 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425306
11.
Determination of the hydration number of gadolinium(III) complexes by high-field pulsed 17O ENDOR spectroscopy.
Chemphyschem
; 7(7): 1590-7, 2006 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16810729
12.
Protein structure determination by high-resolution solid-state NMR spectroscopy: application to microcrystalline ubiquitin.
J Am Chem Soc
; 127(24): 8618-26, 2005 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15954766
13.
Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopy.
Chemphyschem
; 6(12): 2570-7, 2005 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16294353
14.
When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivity.
Chemistry
; 11(20): 5866-74, 2005 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16052656
15.
Characterization of protein-ligand interactions by high-resolution solid-state NMR spectroscopy.
J Am Chem Soc
; 126(43): 13948-53, 2004 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15506755
16.
Electron transfer in cyanobacterial photosystem I: I. Physiological and spectroscopic characterization of site-directed mutants in a putative electron transfer pathway from A0 through A1 to FX.
J Biol Chem
; 278(30): 27864-75, 2003 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12721305
17.
Electron transfer in cyanobacterial photosystem I: II. Determination of forward electron transfer rates of site-directed mutants in a putative electron transfer pathway from A0 through A1 to FX.
J Biol Chem
; 278(30): 27876-87, 2003 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12721306
18.
Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases.
Biochemistry
; 42(19): 5694-705, 2003 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12741826
19.
Assembly of photosystem I. II. Rubredoxin is required for the in vivo assembly of F(X) in Synechococcus sp. PCC 7002 as shown by optical and EPR spectroscopy.
J Biol Chem
; 277(23): 20355-66, 2002 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-11914374