Detalhe da pesquisa
1.
Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.
Bioorg Med Chem Lett
; 26(2): 429-434, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26684851
2.
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
Bioorg Med Chem Lett
; 25(6): 1310-7, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25683622
3.
Evaluation of a Series of ß-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.
ACS Med Chem Lett
; 10(8): 1159-1165, 2019 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31413800
4.
Optimization of 1,4-Oxazine ß-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.
J Med Chem
; 61(12): 5292-5303, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29809004
5.
1,3,5-Trisubstituted Pyrazoles as Potent Negative Allosteric Modulators of the mGlu2/3 Receptors.
ChemMedChem
; 12(12): 905-912, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28263042
6.
1,4-Oxazine ß-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.
J Med Chem
; 58(20): 8216-35, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26378740
7.
Identification of a novel orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor with efficacy in animal models of schizophrenia.
J Med Chem
; 58(2): 978-93, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25495129
8.
Efficient synthesis of enantiomerically pure alpha-alkyl cyclopropanecarbonitrile derivatives from pyrazolines.
Org Lett
; 6(26): 4945-8, 2004 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15606106
9.
Correction to Optimization of 1,4-Oxazine ß-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.
J Med Chem
; 61(24): 11415, 2018 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30525600
10.
Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.
J Med Chem
; 55(6): 2688-701, 2012 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352782
11.
New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.
Bioorg Med Chem Lett
; 16(5): 1392-6, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16321525
12.
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.
Bioorg Med Chem Lett
; 16(13): 3396-400, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16650992
13.
Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.
Bioorg Med Chem Lett
; 15(9): 2279-83, 2005 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15837309