[Lipid peroxidation in acute surgical diseases of abdominal cavity organs]. / Perekisnoe okislenie lipidov pri ostrykh khirurgicheskikh zabolevaniiakh organov briushnoi polosti.

The study of lipid peroxidation (LPO) characteristics in patients with acute mesenterial circulatory disturbances (64), acute pancreatitis (44) and acute bowel obstruction (46) allowed the conclusion on informative value of determination of malonic dialdehyde and diene conjugates in the blood for staging these diseases and the degree of severity of endotoxicosis. On the basis of the state of LPO it became possible to evaluate the extent of bowel failure. According to LPO in postoperative period the process of development of vascular rethrombosis in the bowels could be assessed. The varieties of lipid peroxidation products in peripheral venous blood can be used for differential diagnosis of such diseases, similar in their clinical symptoms, as acute pancreatitis and acute bowel obstruction.

[Clinical-experimental bases of the use of antioxidants in the treatment of mechanical jaundice]. / Kliniko-éksperimental'noe obosnovanie primeneniia antioksidantov v lechenii mekhanicheskoi zheltukhi.

The results of clinical (200 patients) and experimental (30 dogs) studies reported by the authors show that lipid peroxidation in obstructive jaundice plays an essential role in hepatic functional and morphological abnormalities. Current examination methods were used which confirmed the well-known pathophysiological abnormalities in the body of patients with obstructive jaundice leading to marked hypoxia of hepatocytes and proved that lipid peroxidation is significantly intensified in a liver affected by subhepatic cholestasis. The authors suggest their own conception of the pathophysiological and biochemical shifts in the organism of a patient with obstructive jaundice which are capable of causing stimulation of lipid peroxidation and accumulation of highly toxic products of this process in the body. A scheme of prevention and treatment of hepatic insufficiency is suggested for practical surgery by antioxidants of direct and mediated action which were selected from a series of drugs currently in use.

[Use of an antioxidant complex in the treatment of endotoxicosis in reconstructive surgery of lower limb arteries]. / Primenenie kompleksa antioksidantov dlia lecheniia éndotoksikoza pri rekonstruktivnykh operatsiiakh na arteriiakh nizhnykh konechnostei.

During a dynamic examination of 69 patients with obliterating atherosclerosis of the lower extremity vessels who were subjected to different reconstructive operations on the distal portion of the aorta and arteries the content of the dienic conjugate and malonic dialdehyde was studies both before the operation and during different stages of the latter, as well as at the postoperative period. It was found that the patients had higher content of these substances both before and after operations. A scheme is proposed for the complex antioxidant therapy which allows the degree of endotoxicosis resulting from the activation of lipid peroxidation to be decreased.