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1.
Arch Neurol ; 48(8): 822-7, 1991 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-1898256

RESUMO

Disaggregated ventral mesencephalic tissue from single aborted human fetuses of 11 to 18 weeks' gestation was implanted stereotaxically into a consistent striatal site in 12 patients with advanced Parkinson's disease. All were receiving optimum levodopa therapy and were examined preoperatively and at 3,6,9, and 12 months postoperatively. Immunosuppression was not used. There were significant sustained improvements at 12 months in three patients; motor fluctuations were absent in two. There were modest group improvements up to 6 months, with increased quality of "on" and "off" phases, quantity of on times, and specific improvements in contralateral upper limb bradykinesia. Preoperative levodopa requirements were reduced to a mean of 64% at 6 months and 61% at 12 months. Deterioration below baseline ratings occurred in three of nine patients who had consistent follow-up to 12 months. Grafting of midgestational human fetal tissue can lead to improvement in Parkinson's disease. Individual disease severity may be critical, and further trials are needed to identify host factors influencing outcome.


Assuntos
Transplante de Tecido Encefálico , Núcleo Caudado/cirurgia , Transplante de Tecido Fetal , Mesencéfalo , Doença de Parkinson/cirurgia , Adulto , Idoso , Humanos , Levodopa/uso terapêutico , Pessoa de Meia-Idade , Movimento , Doença de Parkinson/tratamento farmacológico , Doença de Parkinson/fisiopatologia
2.
Brain Res ; 589(2): E2-4, 1992 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-1393589

RESUMO

We have evaluated the blood-brain barrier (BBB) in 8 Parkinsonian patients before and after stereotactic implantation of foetal mesencephalon (STIM) and one patient with an adrenal medullary implant. Parenteral administration of dopamine did not reverse Parkinsonism pre-operatively or at 5 days, 1, 2, 3, 4 months and 1 year post-operatively. Apomorphine and domperidone reversed Parkinsonism and produced dyskinesia in all patients pre- and post-operatively. We conclude that the BBB remains intact to dopamine following implantation.


Assuntos
Barreira Hematoencefálica/efeitos dos fármacos , Encéfalo/metabolismo , Domperidona/farmacocinética , Dopamina/farmacocinética , Adulto , Idoso , Apomorfina/administração & dosagem , Apomorfina/farmacocinética , Apomorfina/uso terapêutico , Encéfalo/anatomia & histologia , Domperidona/administração & dosagem , Domperidona/farmacologia , Dopamina/administração & dosagem , Dopamina/farmacologia , Implantes de Medicamento , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/tratamento farmacológico , Doença de Parkinson/metabolismo
3.
J Neurol Sci ; 107(2): 183-90, 1992 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-1564516

RESUMO

Pattern electroretinograms and visual evoked cortical responses following flash and checkerboard pattern reversal stimulation were performed in 7 patients with advanced Parkinson's disease before and after implantation of human fetal ventral mesencephalon to the head of the right caudate nucleus. Six to nine months following surgery there was bilateral enhancement of flash-evoked response amplitudes. Electroretinogram measurements were unchanged. Individual increases in amplitude and decreases in latency were seen following pattern stimulation which were not statistically significant. A relationship between change in dyskinesia, and change in checkerboard pattern stimulation amplitude at 2.4 cycles per degree suggests that amplitude effects at this stimulus frequency are mediated via altered dopaminergic receptor status in the grafted hemisphere. This may be relevant to the mechanisms leading to generalised clinical improvements following this grafting technique.


Assuntos
Transplante de Tecido Encefálico/fisiologia , Núcleo Caudado/fisiopatologia , Eletrorretinografia , Potenciais Evocados Visuais , Transplante de Tecido Fetal/fisiologia , Mesencéfalo/transplante , Doença de Parkinson/cirurgia , Feminino , Humanos , Levodopa/uso terapêutico , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/tratamento farmacológico , Doença de Parkinson/fisiopatologia , Transplante Heterotópico
4.
Neurosurgery ; 33(6): 1065-74, 1993 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-8133992

RESUMO

Proliferation and proto-oncogene expression in 19 meningiomas of typical and atypical histology were analyzed in an attempt to understand the mechanism of growth that characterizes the neoplastic process in these tumors. Proliferation was estimated as the proliferative index by the enumeration of S-phase cells in imprints of tumor tissue exposed to bromodeoxyuridine in vitro, and the gene expression of c-myc, c-fos, c-src, c-H-ras, N-myc, acidic and basic fibroblast growth factor, insulin-like growth factors I and II, platelet-derived growth factor-alpha, and epidermal growth factor was quantified by messenger ribonucleic acid dot-blot hybridization assay. Atypical and malignant tumors had significantly higher proliferative indexes than did their nonmalignant counterparts. Levels of c-myc and c-fos messenger ribonucleic acid were elevated more than fivefold in 72 and 78% of the tumors, respectively, relative to the lowest levels detected in the series. Levels of growth factor messenger ribonucleic acid were sporadically elevated; 37 to 44% of tumors had more than fivefold enhanced levels of acidic and basic fibroblast growth factor. Positive correlations between proliferation and proto-oncogene/growth factor expression were found for c-myc in atypical/malignant tumors and for epidermal growth factor in fibroblastic meningiomas. Deregulated expression of c-myc and c-fos common to both typical and atypical tumors suggests that these are early events in the meningioma tumor process that may disturb the control of cell differentiation and together with fibroblast growth factors are likely to endow the transformed cell with a selective growth advantage by reducing the requirement for exogenous mitogens and by providing a niche for the growth of the tumor clone. Positive correlation of c-myc levels with proliferation in atypical/malignant meningiomas implies that this is a feature of malignancy and indicates continued disruption of the negative regulation of proto-oncogene expression, perhaps by tumor suppressor gene losses, during the course of tumor progression.


Assuntos
Regulação Neoplásica da Expressão Gênica , Neoplasias Meníngeas/genética , Meningioma/genética , Proto-Oncogenes , Divisão Celular , Transformação Celular Neoplásica/genética , Sondas de DNA , DNA Complementar/genética , Substâncias de Crescimento/biossíntese , Substâncias de Crescimento/genética , Humanos , Neoplasias Meníngeas/patologia , Meningioma/patologia , Índice Mitótico , Proto-Oncogene Mas , Proteínas Proto-Oncogênicas/biossíntese , Proteínas Proto-Oncogênicas/genética , RNA Mensageiro/análise , RNA Neoplásico/análise
5.
J Neurosurg ; 92(1 Suppl): 57-60, 2000 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-10616059

RESUMO

OBJECT: Synovial cyst is a recognized but infrequent cause of nerve root or spinal canal compression. The authors undertook a review of 839 decompressive spinal procedures performed over a 5-year period. They found seven cases in which the symptoms were caused by synovial cysts. METHODS: Six of these cases were in a subgroup of 80 patients who were older than 60 years of age, which represents 7.5% of the total for this age group. More than 200 cases of this abnormality have been reported in the world literature, but the incidence, prevalence, and natural history remain unknown. CONCLUSIONS: The authors propose that the incidence of synovial cysts may be more common than recognized in the elderly and suggest that preoperative diagnosis may help limit the extent of the surgical approach.


Assuntos
Neuralgia/etiologia , Radiculopatia/etiologia , Cisto Sinovial/complicações , Cisto Sinovial/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Neuralgia/cirurgia , Prevalência , Radiculopatia/cirurgia , Cisto Sinovial/epidemiologia , Cisto Sinovial/cirurgia
6.
Chaos ; 6(1): 32-42, 1996 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-12780233

RESUMO

Numerous physical systems with two competing frequencies exhibit frequency locking and chaos associated with quasiperiodicity. In this paper we review certain universal aspects of the quasiperiodic route to chaos by making use of the standard circle map. Particular attention is paid to the golden mean and silver mean with a view to comparison with experimental work. (c) 1996 American Institute of Physics.

9.
Artigo em Inglês | MEDLINE | ID: mdl-2672718

RESUMO

Posterior third ventricular masses are uncommon and posterior intraventricular masses are rare. Intraventricular and paraventricular lesions are difficult to differentiate in this region and present particular problems of diagnosis and treatment. Uncertain radiology and frequently confusing histology make treatment planning difficult. The first requirement of histological confirmation of the speculative pathology is best achieved by stereotactic biopsy rather than craniotomy exposure and biopsy, the mortality and morbidity for each being compared. The problem of CSF pathway obstruction can be dealt with by aspiration of the mass or CSF diversion; solid tumours frequently require a definitive shunting procedure while other lesions may not.


Assuntos
Neoplasias do Ventrículo Cerebral/patologia , Ventrículos Cerebrais/patologia , Técnicas Estereotáxicas , Adolescente , Idoso , Biópsia por Agulha , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
10.
Artigo em Inglês | MEDLINE | ID: mdl-2672712

RESUMO

The two possible dopamine donor sites for transplantation are autologous adrenal medulla and human foetal substantia nigra or adrenal medulla. There is increasing experience with the use of adrenal medulla transplantation for Parkinson's disease and much less experience in foetal substantia nigra transplantation. The particular problems of each technique are discussed with examples and postoperative progress of cases with the special emphasis on management problems.


Assuntos
Medula Suprarrenal/transplante , Núcleo Caudado/cirurgia , Mesencéfalo/transplante , Doença de Parkinson/cirurgia , Técnicas Estereotáxicas , Adulto , Avaliação da Deficiência , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Recidiva
11.
Stereotact Funct Neurosurg ; 54-55: 282-9, 1990.
Artigo em Inglês | MEDLINE | ID: mdl-2080343

RESUMO

Twelve patients with advanced Parkinson's disease have been improved by transplantation of fetal mesencephalon into the caudate nucleus. No immunosuppression had been used. The human allogeneic transplantation window is wide.


Assuntos
Transplante de Tecido Encefálico/métodos , Núcleo Caudado/cirurgia , Transplante de Tecido Fetal/métodos , Mesencéfalo/transplante , Doença de Parkinson/cirurgia , Técnicas Estereotáxicas , Adulto , Feminino , Seguimentos , Humanos , Masculino , Mesencéfalo/embriologia , Pessoa de Meia-Idade , Doença de Parkinson/diagnóstico , Complicações Pós-Operatórias/diagnóstico
12.
Artigo em Inglês | MEDLINE | ID: mdl-1792966

RESUMO

Six patients with advanced Parkinson's Disease were evaluated before and after implantation of human fetal ventral mesencephalic tissue to the head of the right caudate nucleus. The results of clinical assessment indicate that attempts to characterise patient fluctuations requires a combination of clinical rating scales and timing of specific limb tasks.


Assuntos
Transplante de Tecido Encefálico/métodos , Corpo Estriado/cirurgia , Transplante de Tecido Fetal/métodos , Mesencéfalo/transplante , Exame Neurológico/métodos , Testes Neuropsicológicos , Doença de Parkinson/cirurgia , Complicações Pós-Operatórias/diagnóstico , Idoso , Feminino , Seguimentos , Humanos , Masculino , Mesencéfalo/embriologia , Pessoa de Meia-Idade
13.
Artigo em Inglês | MEDLINE | ID: mdl-1792968

RESUMO

12 patients with advanced Parkinson's Disease who had right caudate implantations of late stage foetal mesencephalon have been followed up for 1 to 2 years with extensive clinical and physiological assessments. Three patients failed to comply and were excluded. Seven of the remaining 9 patients showed substantial initial improvement which was well maintained in 4. Two of the 3 remaining patients of this group maintained lesser improvement. One returned to pre-operative state. Two patients with greatly advanced disease had only slight but brief improvement. A series of 24 matched patients have been treated and continue under investigation.


Assuntos
Transplante de Tecido Encefálico/métodos , Núcleo Caudado/cirurgia , Transplante de Tecido Fetal/métodos , Mesencéfalo/transplante , Exame Neurológico , Doença de Parkinson/cirurgia , Complicações Pós-Operatórias/cirurgia , Putamen/cirurgia , Adulto , Idoso , Feminino , Seguimentos , Humanos , Masculino , Mesencéfalo/embriologia , Pessoa de Meia-Idade , Projetos Piloto
14.
Br J Neurosurg ; 5(4): 331-8, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1786127

RESUMO

CT-guided stereotactic biopsy is now an accepted method of tissue sampling in intracranial mass lesions but many surgeons still practise freehand burrhole biopsy. This study compares two groups of patients who had either stereotactically guided (n = 153) or freehand (n = 217) biopsy. Stereotactic biopsy has a lower incidence of both mortality (2.6%) and morbidity (1.3%) than freehand (7.8 and 7.8%) while diagnostic accuracy is 92.1 and 64.9%, respectively. The success rate for stereotactic biopsy is independent of the size and depth of the lesion while freehand biopsy is most successful for large, superficial lesions but its success never exceeds 88%. The stereotactic technique is superior to the freehand for all intracranial biopsies regardless of size or site.


Assuntos
Biópsia/métodos , Técnicas Estereotáxicas , Neoplasias Supratentoriais/patologia , Adulto , Idoso , Biópsia/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/mortalidade , Estudos Retrospectivos , Sensibilidade e Especificidade , Neoplasias Supratentoriais/diagnóstico por imagem , Taxa de Sobrevida , Tomografia Computadorizada por Raios X
15.
J Neurol Neurosurg Psychiatry ; 55(7): 590-3, 1992 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-1640237

RESUMO

Stereotactic linear accelerator (linac) radiosurgery has been in operation in the West Midlands since 1987, the first of its kind in the United Kingdom. Forty two patients with high-flow cerebral arteriovenous malformations have been treated, 26 of whom have been followed up. Angiography one year after treatment showed that five lesions were obliterated, 11 were reduced in size and/or flow rate and 10 were unchanged. Overall results show that nine out of 10 patients reviewed at 24 months had total obliteration. Three patients had complications; one has fully recovered, one died of an unrelated cause at 36 months and the other died from recurrent haemorrhage at nine months. Two patients had recurrent non-fatal haemorrhage within 24 months of treatment; both recovered without further deficit. All patients are fit to work but eight are unemployed. Although the follow up period is short, the early results indicate a success rate similar to those published by others using linac radiosurgery.


Assuntos
Malformações Arteriovenosas Intracranianas/cirurgia , Radiocirurgia/instrumentação , Técnicas Estereotáxicas/instrumentação , Adolescente , Adulto , Idoso , Angiografia Cerebral/instrumentação , Hemorragia Cerebral/diagnóstico , Hemorragia Cerebral/cirurgia , Criança , Sistemas Computacionais , Feminino , Seguimentos , Humanos , Malformações Arteriovenosas Intracranianas/diagnóstico , Imageamento por Ressonância Magnética/instrumentação , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico , Planejamento da Radioterapia Assistida por Computador/instrumentação , Tomografia Computadorizada por Raios X/instrumentação
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