Detalhe da pesquisa
1.
Understanding Exposure-Receptor Occupancy Relationships for Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators across a Range of Preclinical and Clinical Studies.
J Pharmacol Exp Ther
; 377(1): 157-168, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33541889
2.
A novel somatostatin receptor ligand for human ACTH - and GH -secreting pituitary adenomas.
Eur J Endocrinol
; 190(1): K8-K16, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123488
3.
The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders.
ACS Med Chem Lett
; 14(4): 499-505, 2023 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37077397
4.
Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Bioorg Med Chem Lett
; 21(12): 3813-7, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21596563
5.
The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.
Bioorg Med Chem Lett
; 21(10): 3163-7, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21458261
6.
Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Bioorg Med Chem Lett
; 21(6): 1871-5, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21353540
7.
Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918.
Heliyon
; 7(6): e07201, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34189291
8.
Gastrointestinal and metabolic function in the MPTP-treated macaque model of Parkinson's disease.
Heliyon
; 6(12): e05771, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33385085
9.
Assessment of seizure liability of Org 306039, a 5-HT2c agonist, using hippocampal brain slice and rodent EEG telemetry.
J Pharmacol Toxicol Methods
; 70(3): 224-9, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25150935
10.
Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding.
J Psychopharmacol
; 25(2): 211-21, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20093322
11.
Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal response of chronically stressed rats to a heterotypic stressor.
J Endocrinol
; 200(3): 285-91, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19074473
12.
Blockade of the V(1b) receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic-pituitary-adrenal axis activity.
J Endocrinol
; 200(3): 273-83, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19008333
13.
Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release.
J Endocrinol
; 196(2): 323-30, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18252955
14.
Characterization of a novel and selective V1B receptor antagonist.
Prog Brain Res
; 170: 527-35, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18655906