1.
Bioorg Med Chem Lett
; 11(7): 895-8, 2001 Apr 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11294386
RESUMO
The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.