1.
Bioorg Med Chem Lett
; 24(13): 2815-9, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24835628
RESUMO
We report the synthesis and biological evaluation of three analogues of the natural product (+)-grandifloracin (+)-1. All three analogues exhibit enhanced antiproliferative activity against PANC-1 and HT-29 cells compared to the natural product. The retention of activity in an analogue lacking the enone functional group, 9, implies this structural element is not an essential part of the (+)-grandifloracin pharmacophore.