ABSTRACT
Prostate cancer [PCa] is a public health issue still targeted by many studies. Unfortunately, data on that cancer are rare in Northern Africa and especially in Morocco. We present characteristics of this type of cancer. From February 2003 to March 2010, 162 PCa were diagnosed in our institution, 41 of them with PSA < 10ng/mL. In those patients, we analyzed the age, symptoms, PSA level including the free/total ratio, pathological report on biopsy, preoperative imaging [pelvic MRI and bone scintigraphy] data, therapy including adjuvant or salvage management, pathological report on specimens, and follow-up data [PSA, urinary continence, potency, mortality]. The mean age of the 41 patients was 63.93 years [range: 47-77]. PSA dosage was performed in 85.4% of them as they consulted for low urinary tract symptoms. Median PSA level was 5.76ng/mL [range: 1.26-10] at diagnosis; the mean free/total PSA ratio was 13.77%. All 41 cancers were adenocarcinomas. 87.8% of them were clinically organ-confined. According to D'Amico classification, 65.85% were low risk, 9.76% were intermediate risk and 24.39% were high risk cancers. The Gleason score at biopsy was 7[4+3] or less. Radical prostatectomy was performed in 95.12% of patients. 7.69% were pT3b, all of others were pT3a or less; the Gleason score was 6 or less in 73.34% specimens and surgical margins were positive in 30.77% of specimens. Post-prostatectomy PSA increased in 26.83% of cases. Adjuvant radiation and hormonal therapy were used in 34.15% of patients. 90.24% of the patients proved undetectable PSA on latest dosage while only 2.34% experienced biochemical recurrence. 82.05% of the patients were continent, 33.33% of them were potent. This cancer were diagnosed in younger men; 87.8% of those cancers were organ-confined; treatment option were radical prostatectomy with excellent disease-free survival rate