ABSTRACT
Background and Objective: Alpha lipoic acid [ALA] is a powerful biological antioxidant which is involved in metabolism and energy production as a co-factor in mitochondrial dehydrogenase enzyme complex. This study was done to evaluate the effect of aerobic exercise and alpha lipoic acid supplement on insulin resistance in females with type 2 diabetes
Methods: In this quasi-experimental study, 44 females with type 2 diabetes divided into four groups including: control, supplementation, training and supplementation + training groups. Patients of supplementation and complex [supplementation + training] groups took three 100mg ALA capsules per day for eight weeks. The training program consisted of 8 weeks and three sessions per week. In each session, the subjects warmed up for 10-15 minutes, ran on a treadmill with the intensity of 40-50% of maximum heart rate for 30 minutes and then cooled down for 5-10 minutes. Blood samples were taken after 12-14 hours fasting in two stages - the beginning and the end of the eighth week
Results: Eight weeks of taking ALA supplements significantly reduced patients' insulin resistance [P<0.05]. Eight weeks of running on a treadmill with an intensity of 40-50% of maximum heart rate nonsignificantly reduced insulin resistance in the training group compared to the controls. In the supplementation + training group a significant reduction of insulin resistance was observed [P<0.05]
Conclusion: Alpha lipoic acid supplementation reduces insulin and insulin resistance. While, reduction in fasting blood glucose level causes reduction in insulin resistance in the combination of supplementation and training