ABSTRACT
The aim of the present study was to prepare an oral tablet from liquid yogurt by reforming the physical properties for easy transportation, long-term storage and also as a complementary dairy product in case of nutrient deficiency. The liquid fresh yogurt was lyophilized at -40°C and 0.03 mTor pressure. The dry powder was homogenized by a 12 mesh size sieve. Some tests such as Carr's compressibility index, Hausner ratio and the angle of repose were applied to evaluate the flowability of yogurt powder. Study of the deformation of particles during forcing was done by calculation of the elastic recovery index. Carr's compressibility index percent and Hausner ratio were calculated 15 and 0.94, respectively. The range of repose angle was measured between19-20. The elastic recovery was obtained up to 60%. Since the hardness of tablets increased by decreasing compression velocity, therefore yogurt powder might have a plastic deformation. The reduction of powder volume due to compression force was about 20% [p < 0.05]. Tablets with low fat yogurt showed very good compressibility with 6-12 Strong-Cab [SC] hardness units. Producing a complementary formulated as a tablet from yogurt powder is possible and also maybe therapeutically effective against lactose-intolerance syndrome and preventing antibiotic-associated diarrhea.We suggest that for more authentic confirmation of the type of deformation, it should go through Heckel's equation analysis, too
Subject(s)
Tablets/chemistry , Hardness , Dairy Products , Drug Compounding , Freeze DryingABSTRACT
Compounds present in green tea have proved to inhibit the growth and activity of bacteria associated with infections. To assess the effects of green tea leaves extract in presence of propylene gly-col on the aerobic mouth bacteria load. Saliva of 25 volunteer girl students aging 20-25 years were selected and evaluated by a mouth wash sample containing 1% tannin, as the most effective antibacterial complex in green tea. Comparative studies were also conducted between green tea mouthwashes containing 1% tannin and a similar sample with 10% propylene glycol added during extraction. This comparison was applied for a chlorhexidine 0.2% sample as a chemical mouthwash brand, too. There was a meaningful difference between the green tea mouthwashes containing 10% propylene glycol and the simple green tea extract [P < 0.05]. Significant difference was also seen between the herbal and chemical mouthwashes [P < 0.05]. The extract 1% tannin containing 10% propylene glycol reduced the aerobic mouth bacterial load of the student salvia about 64 percent. The pH monotonousness in different days and temperatures approved the stability of tannin in liquid water medium. Using green tea extract as a herbal mouthwash is safe and harmless specially for children and pregnant women. This result led us to suppose that green tea may prevent plaque formation on teeth, coming over halitosis due to mouth infection, too. These effects need to be approved in an in vivo trial as a second study
ABSTRACT
Wound repair is a natural reaction to injury, which results in restoration of tissue integrity. Wound healing occurs in 3 phases including inflammation, proliferation, and remodeling. There are common pathways in wound healing of human and certain animal species. To examine the healing effect of tragacanth mucilage on excisional full-thickness wound in rabbit. Mucilage was extracted from the dried tragacanth gum, using a mixture of water and glycerin [4:1] as the vehicle. Three percent, 6%, and 9% creams of tragacanth mucilage were prepared in the eucerin base. A full-thickness wound was made on the left flank of rabbits. Tragacanth creams were applied on the wound area twice daily. Control groups were treated with the drug-free cream base or commercial phenytoin cream 1%. Healing was determined quantitatively as the reduction in wound area. Histological study was performed using hematoxylin and eosin stain under light microscope. The wound healing profile of tragacanth-treated groups was significantly better than the nontreated groups. The best healing effect was observed with the 6% tragacanth cream, which exerted the lowest period for healing. This effect was significantly different from the control phenytoin or drug-free eucerin bases. The extent of tissue repairment was confirmed by histological examination. Tragacanth mucilage exhibited a considerable potency for wound healing. This is probably due to an acceleration of collagenation and proliferation phases of the wound repair