ABSTRACT
Background:Transfusion transmissible infections (TTIs) are one of the major adverse effects of blood transfusion. Serological testing can reduce, but not eliminate the occurrences of TTIs. Study of TTIs amongst blood donors could help to find safe blood for the patients.Aims:This study was conducted to evaluate the prevalence of markers of Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), Syphilis and Malaria among Voluntary Blood Donors and Replacement Blood Donors in a tertiary care centre.Materials and Methods: Aretrospective study was conducted at The State of the art Model blood bank, Pt. Jawaharlal Nehru Memorial Medical College (JNMMC) and Dr. B. R. Ambedkar Memorial Hospital, Raipur, Chhattisgarh. This study included all the blood donors both from in-hospital donations and outdoor camps donations (including Voluntary and Replacement donors) from January 2011 to December 2018. Enzyme-linked immunosorbent assay (ELISA) test was done for screening of HBV, HCVand HIV; Rapid Plasma Reagin (RPR) test was done for syphilis and Card Test for Malaria Antigen.Results:Atotal of 1,08,577 donors were screened over a period of eight years. The seroprevalence of HIV, HBV, HCV, syphilis and malaria was found to be 0.12%, 0.77%, 0.04%, 0.22% and 0.03% respectively. Overall seroprevalence of reactive TTIs was 1.19%, which was maximum in the year 2013 (2.28%) after that there was a gradual decrease in the prevalence rate of TTIs in blood donors over the years. Infections were more common among Replacement Donors as compared to Voluntary Donors. Conclusion: The increase in public awareness regarding Voluntary blood donation, meticulous donor screening, counselling and use of highly sensitive tests can help in reducing the risk of TTIs. Prevalence of HIVinfection is decreasing in the blood donors. The HBVinfection still remains a menace to be tackled. HCV, Syphilis and malaria maintain a low rate of positivity. Methods to ensure a safe blood supply should be encouraged.
ABSTRACT
Background: Blood safety a major issue in the field of transfusion medicine. Persons who are disqualified or rejected fromdonating blood are known as “deferred” donors. Deferrals lead to loss of precious blood/components available for transfusion.For preventing this, we should be having knowledge of the causes of deferral and their frequency. To make blood transfusionsafe for the patients, many safety measures are undertaken and the most important is a selection of the suitable blood donors.Hence, it is important to analyze the reasons and rate for donor deferral and retain the motivated donors.Aims: This study aims to evaluate and analyze the reasons of predonation deferrals.Materials and Methods: In this retrospective study, causes of donor deferral were evaluated retrospectively including both inhospital donations (and outdoor camp donations) including voluntary and replacement donors from January 2016 to December2018 in the State of the Art Model blood bank of Dr. B. R. Ambedkar Memorial Hospital and Pt. Jawaharlal Nehru MemorialMedical College, Raipur, Chhattisgarh, India.Results: Among 53,245 donors registered, 1894 (3.56%) were deferred from blood donation. Temporary deferrals weresignificantly higher than permanent deferral. The most common reasons for temporary deferral were anemia, followed byunderweight, recent medication, high blood pressure (BP), and low BP and so on. The common causes for permanent deferralincluded being overage, diabetes, asthma, heart disease, hepatitis B surface antigen positivity, and epilepsy and so on.Conclusion: Creating public awareness on common causes of donor deferral may help to lower the deferral rates as well aspromote the retention of potential donors.
ABSTRACT
Introduction: Cleft lip/palate are the most common craniofacial anomalies in children, with an incidence of CLP worldwide is 1 in 700 live births. The risk factors are considered as Family history etc. Anaesthesia during cleft lip and palate surgery carries a high risk and difficult airway management in children. Because of other associated congenital anomalies, the anaesthetic management becomes more complicated. Flexometallic endotracheal tubes, PVC macintosh tube, RAE tube are have their own risks and benefits when compared with each other. This study was undertaken to compare ease of intubation ,ease of ventilation ,intra operative maintenance of respiratory parameters ,intra-operative airway complication, post extubation complication by using 3 different types of tubes (1) RAE (Ring Adair Elwyn) tube (2) flexometallic tube (3) PVC ( Polyvinyl Chloride) macintosh tube in pediatric cleft palate surgeries. Material & Methods: A randomized controlled trial was conducted on 90 ASA I and ASA II pediatric patients of age group 9 month to 5 years undergoing cleft palate surgeries. Patients were randomly allocated in three groups of 30 each. Group 1: intubated with R A E endotracheal tube, Group 2:intubated with flexometallictube and Group 3: intubated with P V C macintosh endotracheal tube. The power of study on choosing such sample size was found to be at 90% level. Time taken for intubation, No. of attempt taken for intubation, Monitoring of capnography, SPO2, pulse rate and mean airway pressure every 15 minutes during the surgical procedures, Endobronchial intubation, Inadvertent extubation, Ease of passing of suction catheter after application of dingman retractor and Post extubation cough and croup was observed. Results: The significant differences were observed in stylet used, ease of passing suction catheter and post extubation cough and heart rate after retractor among the groups (p<0.05). All other differences were found to be insignificant. Conclusion: RAE tube provides a good approach for airway management in routine cleft lip surgeries. It possesses advantage over flexometallic tube and PVC tube. As it is a preformed tube passing suction catheter is technically difficult.