case of gllucagonoma and a review the literature

Glucagonoma is a rare islet cell tumor [alpha cell tumor] of the pancreas, when active it produces a syndrome characterized by necrolytic migratory erythema, diabetes mellitus, weight loss, anemia, glossitis, thromboembolism, neuropsychatric disturbances and hyperglucagonaemia. We present a case of a large pancreatic head tumor with diabetes mellitus [DM], anemia, weight loss and muscle wasting. After complete resection of the pancreatic tumor, the hyperglycaemia subsided. Peviewing 120 cases of glucagonoma in the literature the average tumor diameter was 3.6 cm. Most of the tumors [90%] occurred in the body and the tail. Two thirds of the reported glucagonomas were malignant and 53.3% metastasizes to other organs. Necrolytic migratory erythema [NME] is not a prerequisite for the diagnosis of Glucagonoma syndrome, where anemia, hyperglycemia, muscle wasting and weight loss may be the presenting features

Castleman's Disease: two case reports, with review of literature

Castlemann's Disease [CD] is a rare disorder characterized by a benign atypical proliferation of lymphatic tissue, and can occur anywhere along the lymphatic channels in either localized or multicentric [systemic] forms. Most cases occur as a mediastinal mass, although about one quarter of cases presented as neck and abdominal masse whether nodal or extra nodal. We present tow patients, one is a 58-years old man with localized cervical mass, who was treated successfully by local excision. The other is a 30-yeasr old female complaining form a retroperitoneal mass abutting the caudate lobe of the liver, mistaken as liver haemangioma, which was then successfully removed laparoscopically. More than three years of follow-up with no recurrence noticed