ABSTRACT
Introdução: a esclerose sistêmica progressiva acomete diversas vísceras, das quais o esôfago é uma das frequentemente lesadas. No entanto, o mecanismo de autoimunidade nesta enfermidade é ainda desconhecida...
Backgrounds: Sclerosis systemic that usually affects the esophagus. However its patologic mechanism is still unknown. Objective: Evaluate the manifestation of the esophagus in a experimental model of scleroderma induced by type V collagen in rabbits. Matherial and Methods: 39 rabbits submited to the model immunization were morfologicaly analised. Results: A progressive deposit of collagen fibers was observed in H&E and Tricomico of Masson. Which was confirmed by the imunofluorescence. Conclusion: We concluded that the characteristics observeds are similar to what happens in the esophagus of human, but in an earlier period...
Subject(s)
Animals , Rabbits , Collagen Type V , Scleroderma, Localized , Esophageal Diseases , Models, Animal , Disease Progression , RabbitsABSTRACT
A estenose traqueobrônquica é uma condição que cursa com dispnéia, estridor e pneumonia obstrutiva, causada por diversas condiçoes como tumores, compressão extrínseca e traqueobroncospia, porém a causa. mais frequente é a complicação resultante de intubação prolongada...
Tracheobronchial stenosis curses with dyspnea, stridor and obstructive pneumonia, and can be caused by tumors, extrinsic compression and tracheobronchomalacia, butthe most frequent cause is the sequel resulting of prolonged intubation, occurring in about intubations. The treatment of choice for such condition is resection of the compromise segment; however this procedure isn´t possible in every patient and this led to the development of endoscopic palliative technique. Tracheobronchial stentintg is between one of such techniques that obtain the best results. Tracheobronchial stents can be divided manly between silicone tubes and self-expandable metallic stents, each one with specific advantages and disadvantages. The present study presents the main stent models, comparing their advantages and disadvantages and complications rates, aiming to systematize the ideal indications for every type of stent...
Subject(s)
Constriction, Pathologic , Dyspnea/etiology , Prostheses and Implants , Trachea/surgery , StentsABSTRACT
Os pacientes com derrame pleural maligno (DPM) têm neoplasias em fase avançada com mau prognóstico e baixa resposta a tratamento sistêmico. Devido à curta expectativa de vida e ao controle muitas vezes ineficaz pela quimioterapia, quando se apresentam muito sintomáticos alguma terapêutica paliativa efetiva é necessária para oferecer conforto e qualidadede vida a estes pacientes. Porém, visto a grande variedade de apresentações clínicas, a terapêutica ideal não deve ser generalizada para todos os pacientes com DPM, como é pode ser observado em muitos ensaios clínicos sobre o assunto. Esta deve ser individualizada considerando principalmente a performance status e as condições clínicas do paciente. Revisamos as várias opções terapêuticas descritas na literatura para o tratamento de pacientescom DPM, propondo uma abordagem individualizada destes pacientes, de acordo com a suas...
Malignant pleural effusion (MPE) patients have advanced neoplasms with bad prognosis and low response of systemic therapy. When symptomatic, a palliative treatment is mandatory in order to offer comfort and quality of life to these patients. Several options areavailable, as ambulatory procedures and video assisted thoracic surgery. The clinical efficacy of these methods is a matter of debate and subject of many papers. Because of the high varietyof clinical presentations, no single method should be considered as a gold standard procedure, rather the management should be individualized considering the performance status and clinical condition of the patient. We reviewed the options described in the literature for the treatment ofMPE and proposed an individualized management strategy for these patients according to their clinical presentation...