ABSTRACT
Background: Systemic amyloidosis is a rare disease that can affect any organ. Its clinical manifestations are varied and nonspecific. The skin involvement of this disease is common and can be easily recognized on physical examination. We report a 57-year-old male presenting with a two years history of malaise, dyspnea and myalgias. On physical examination, ungueal dystrophy, orange pigmentation of eyelids with periocular petechiae and mild macroglossia were observed. Incisional biopsies of the eyelids, cheeks and hands were obtained. The pathological study demonstrated amyloid deposits. Since protein electrophoresis was normal, the diagnosis of AA amyloidosis was postulated.
Subject(s)
Humans , Male , Middle Aged , Amyloidosis/pathology , Skin Diseases/pathology , BiopsyABSTRACT
La enfermedad de Behçet es una vasculitis inflamatoria sistémica que se caracteriza clásicamente por episodios recurrentes de úlceras orales y genitales asociadas a uveítis. Además se han descrito otras manifestaciones como artritis, lesiones cutáneas, compromiso neurológico, gastrointestinal y vascular. Sólo pequeñas series de EB en el embarazo han sido publicados, con resultados pronósticos dispares. Las remisiones tienden a ser más frecuentemente reportadas debido a la inmunodepresión tanto humoral como celular presente en la gestación. Sin embargo, exacerbaciones con complicaciones tales como fenómenos tromboembólicos, síndrome de Budd Chiari y encefalitis también han sido descritas con una tendencia a mantener a largo plazo cualquiera de estos dos cursos posterior al embarazo. Reportamos el caso de una paciente evaluada a partir de la semana quince de gestación que evolucionó con una exacerbación de la EB durante el embarazo, la cual persistió y fue progresiva posterior al parto.
Behçet disease (BD) is a systemic immflamatory vasculitis that is characterized by recurrent episodes of oral and genital ulcers associated with uveitis. Artritis, cutaneous lesions and neurological, gastrointestinal and vascular impairment are other associated manifestation. In the medical literature few series of cases of Behçet disease in pregnancy have been reported each of them with different prognosis. Remissions are more frequent during pregnancy due to both humoral and cellular immune suppression. Exacerbation of the disease and complications such as thromboembolism, Budd Chiari syndrome and encephalitis have also been described with tendency. We report the case of a pregnant woman assessed from the 15th week of gestation who attended with an exacerbation of BD during pregnancy, which was progressive and persisted after delivery.
Subject(s)
Humans , Adult , Female , Pregnancy Complications/etiology , Behcet Syndrome/diagnosis , Behcet Syndrome/drug therapy , Colchicine/therapeutic use , Prednisone/therapeutic useSubject(s)
Humans , Male , Child , Cold Temperature/adverse effects , Urticaria/diagnosis , Urticaria/etiology , Diagnosis, DifferentialABSTRACT
La Dermatosis IgA lineal es una enfermedad vesiculoampollar subepidérmica autoinmune caracterizada por anticuerpos IgA en la unión dermoepidérmica. Es una enfermedad poco frecuente, siendo la mayoría de los casos idiopáticos, pero con reporte de casos por medicamentos, infecciones virales, enfermedades autoinmunes y tumores malignos. Se presentará un caso clínico de Dermatosis IgA lineal causada por Diclofenaco.
Linear IgA dermatosis is an autoimmune subepidermal vesiculobullous disease characterized by IgA antibodies at the dermo-epidermal junction. It is an uncommon disease, with most cases idiopathic, but with case reports caused by drug, viral infections, autoimmune diseases and malignant tumors. A clinical case of Linear IgA dermatosis caused by diclofenac is presented.
Subject(s)
Humans , Adult , Female , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Linear IgA Bullous Dermatosis/chemically induced , Linear IgA Bullous Dermatosis/drug therapy , Diclofenac/adverse effects , Autoimmune Diseases , Linear IgA Bullous Dermatosis/pathology , Fluorescent Antibody Technique, DirectABSTRACT
El síndrome de Sweet en pacientes con cánceres sólidos es muy poco frecuente. En una búsqueda exhaustiva en la literatura se encuentra en relación a cáncer bronquial, de mama, de próstata, gástrico, mas no en relación a cáncer de ovario. Este es un reparte de una paciente de 64 años con cáncer de ovario recidivado con lesiones nodulares eritematosos en extremidades superiores e inferiores.
Sweet's Syndrome in patients with solid cancer is infrequent. In an in-depth review of the literature it is related to lung breast prostate, and gastric cancer, but not to ovarian cancer. We present the case of a 64-year-old female patient with ovarian cancer recurrence with nodular erythematous injuries in her upper and lower extremities.