The Study on Pattern of External Injuries During Road Traffic Accidents of Helmeted and Non Helmeted Victims at Tertiary Care Centre

Background: Motor Vehicle crashes are a remarkable reasonfor casualty all over throughout the world. By 2020, enginevehicle damage is predictable to wind up noticeably the thirddriving supporter of the international weight of illness on theglobe.Methods: The study was conducted for the period of one yearand One hundred subjects were studied at Department ofForensic Medicine &Toxicology S.N. Medical College Jodhpur.Subsequent information was collected from the study: Type ofInjuries (Grievous or Non grievous), Alcohol intake present orabsent, Number of Abrasions/ Bruises/Lacerations andGlasgow Coma Scale. Data was collected and tabulated.Statistical analysis was done. For quantitative data ‘t’ test wasused and for qualitative chi-square test was used. The ‘p’ value<0.05 is considered as statistically significant.Results: Out of total 100 patients, 55 helmeted and 35 nonhelmeted individuals, 22 and 23 persons sustained grievousinjuries respectively. In case of helmeted individuals, thepresence and absence of alcohol intake was observed in 26and 29 cases respectively. Out of 55 helmeted persons 54persons sustained abrasions, 39 had bruises and 17individuals had lacerations. The Glasgow Coma Scale (GCS)score between 3-7 and 8-15 of helmeted individuals were 20%and 80% of the individuals respectively.Conclusions: Serious injury has been found more in nonhelmeted individuals in comparison to helmeted individuals.Alcohol intake has been found more in helmeted individuals incomparison to non-helmeted individuals. The most commoninjury in helmeted individuals has been found to be abrasion.Lacerations have been found more in non-helmetedindividuals. GCS of less than 7 was found to be in more in nonhelmeted individuals in comparison to the helmeted individuals

The study of adverse drug reactions of antihypertensive medicines in essential hypertension patients in Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India

Background: Every drug has the potentiality to cause an adverse drug reaction (ADR). ADRs are a major problem in drug therapy .The aim of this study was to assess the incidence and causality of ADRs to antihypertensive agents used for the essential hypertensive patients attending at the general medicine out patients departments of Hi-Tech Medical College and Hospital, Bhubaneswar Odisha, during the time period of November 2016 to October 2018.Methods: This prospective-observational study was carried out in general medicine outpatient department of Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha.Results: Out of 254 patients, 78 (30.71%) patients were developed ADRs to antihypertensive drugs. 51 (65.38%) were female and 27 (34.62%) were male. Calcium channel blockers were the commonest therapeutic class of antihypertensive drugs associated with ADRs (n = 50, 64.10%). According to WHO causality assessment scale most of the ADRs were “probable” 41 (52.56%), followed by “possible” 21 (26.92%), unclassifiable 13 (16.67%) and unlikely 3 (3.85%).Conclusions: The results of this study concluded that antihypertensive drugs able to induce the development of adverse drug reactions, which were significant cause of increase burden on health care system and decrease the quality of life, the health care professionals should take care about the rational use of antihypertensive agents. Thus, to minimize the incidence of adverse drug reaction and to increase the quality of life.

Quantitative histology-based classification system for assessment of the intestinal mucosal histological changes in patients with celiac disease

BACKGROUND/AIMS: The existing histological classifications for the interpretation of small intestinal biopsies are based on qualitative parameters with high intraobserver and interobserver variations. We have developed and propose a quantitative histological classification system for the assessment of intestinal mucosal biopsies. METHODS: We performed a computer-assisted quantitative histological assessment of digital images of duodenal biopsies from 137 controls and 124 patients with celiac disease (CeD) (derivation cohort). From the receiver-operating curve analysis, followed by multivariate and logistic regression analyses, we identified parameters for differentiating control biopsies from those of the patients with CeD. We repeated the quantitative histological analysis in a validation cohort (105 controls and 120 patients with CeD). On the basis of the results, we propose a quantitative histological classification system. The new classification was compared with the existing histological classifications for interobserver and intraobserver agreements by a group of qualified pathologists. RESULTS: Among the histological parameters, intraepithelial lymphocyte count of ≥25/100 epithelial cells, adjusted villous height fold change of ≤0.7, and crypt depth-to-villous height ratio of ≥0.5 showed good discriminative power between the mucosal biopsies from the patients with CeD and those from the controls, with 90.3% sensitivity, 93.5% specificity, and 96.2% area under the curve. Among the existing histological classifications, our quantitative histological classification showed the highest intraobserver (69.7%–85.03%) and interobserver (24.6%–71.5%) agreements. CONCLUSIONS: Quantitative assessment increases the reliability of the histological assessment of mucosal biopsies in patients with CeD. Such a classification system may be used for clinical trials in patients with CeD.

Utility of Placental Umbilical Cord Blood in Autoimmune and Degenerative Disorders

Background: Umbilical cord blood is whole human blood (60 to 80 ml) that remains in the placenta and umbilical cord after childbirth; generally considered as a medical waste. It is a rich source of stem cells, growth factor, cytokines, etc., and, can be collected, stored and utilized in the treatment of incurable diseases. Aims and Objects: The aim of the present study is to establish the fact that placental umbilical cord whole blood is a safe alternative to adult blood and to assess its utility in degenerative and autoimmune disease along with its hematological parameters. Materials and Methods: It is a prospective two year study (From September 2016 to August 2018) of 250 umbilical cord whole blood transfusions in autoimmune and degenerative disorders at Gajra Raja Medical College, Gwalior, India. Follow up of patients was done up to 3 months and data was collected and analyzed statistically by frequency distribution and percentage proportion. Results: A total of 250 units meeting the inclusion and exclusion criteria were transfused to 99 preregistered patients; Vitiligo 61 (159 transfusions), Thalassemia 15 (30), Retinitis Pigmentosa 9 (23), Geriatric Disorders 9 (24), Aplastic anemia 4 (9) and High Myopia 1 (5). Out of 250 transfusions, in one case (0.4%) adverse event was reported. Outcome of transfusion reveals; In Vitiligo –regimentation in affected area, Thalassemia-reduction in frequency of transfusions, Retinitis Pigmentosa- improvement in vision area, Geriatric patients- sense of well being, Aplastic anemia- prolonged survival and High Myopia-improvement in vision area. Conclusion: Umbilical cord blood is safe and genuine alternative of adult blood. It is effective in degenerative and autoimmune diseases. It should not be discarded as medical waste and utilized judiciously in the human well being.