ABSTRACT
@#Introduction: Diabetes characterized by hyperglycemia can cause long term damages and malfunction of different organ and systems, especially the eye, kidney, nerve and cardiovascular systems. The main problem in Diabetes Mellitus patients is a difficulty in regulating blood glucose levels. Various attempts were made to reduce blood sugar levels so that patients can be free from insulin. Exercise and diet are the primary therapies in DM patients, but apart from that, relaxation techniques can help patients reduce stress and anxiety levels, which will ultimately have a good effect on lowering glucose levels in the blood. Benson relaxation techniques modified with aromatherapy are expected to provide a relaxing effect so that this condition can have a better impact on reducing blood glucose. The present study aims to look at the effect of Benson relaxation exercises and aromatherapy on blood glucose levels. Methods: The researchers intervened in two groups of respondents. The intervention group conducted Benson relaxation exercises and aromatherapy while the control group only conducted Benson relaxation. Results: Differences in the average blood glucose levels before and after exercise in the intervention group and in the control group has been observed. Relaxation conditions will provide a good impact for DM patients because at the time of relaxation stress hormones that trigger an increase in blood glucose levels, will not be released by the body. Conclusion: Present study shows that Benson relaxation exercise and aromatherapy is effective for lowering glucose levels.
ABSTRACT
@#Introduction: Worldwide, breast cancer is the most life-threatening disease among women. There is always high search to find a cure for cancer. Plant compounds have been identified that they have anti-cancer properties. Therefore, phyto-compounds can be potential for the development of new drugs. In this research, three-dimensional (3D) structure of breast cancer cell line proteins, tumor suppressor gene (p53), caspase-3 and retinoblastoma-1 were generated and docking with plant compounds (garcinone E, triterpenoid and gallic acid respectively) was studied. Methods: The three-dimensional models of proteins were built using SWISS model. Then, the physical and chemical characters of the protein models were determined using ExPASy - ProtParam tool. Next, the proteins were assessed using validation tools such as PROCHECK, ProQ, ERRAT and Verify 3D programs. Results: The results show that the proteins were stable. Lastly, the protein models were docked successfully with garcinone E, triterpenoid and gallic acid respectively using BSP-slim server. The docking scores of the protein-phyto-compound complexes (p53-garcinone E, caspase-3- triterpenoid and Rb1-gallic acid) were 3.873, 4.321 and 3.051 respectively. The proteins had a stable bond with phyto-compounds. Conclusion: The study of the protein-phyto-compound complex interaction will aid in designing new clinical drugs.
ABSTRACT
In 2020 a significant threat to public health emerged. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic outbreak emerged in December 2019 from Wuhan City, Hubei Province, China and spread to the rest of the world. This disease was named COVID-19 by World Health Organization. To date (17th April 2020) a total of 2,230,439 cases of COVID-19; 150,810 cases of deaths and 564,210 recovered cases have been reported worldwide. In this review the SARS-CoV-2 morphology, pathogenic mechanism, similarities and differences between SARS-CoV and Middle East Respiratory Syndrome and severe acute respiratory syndrome, transmission mode, diagnosis, treatment, and preventive measures were investigated. The outbreak of COVID-19 from a Malaysian perspective was explored and mental health care during the COVID-19 outbreak was explored. To date, there is no vaccine or no specific treatment for COVID-19. Therefore, preventive measures are very important to prevent and control the rapid spread of the SARS-CoV-2 virus. Preparedness should be a priority for future pandemic outbreaks.