Aumento de la capacidad de conjugación del acetaminofene en colestasis experimental / [Increase of acetaminophen conjugation ability in experimental cholestasis]

Acetaminophen glucuronidation ability and its relationship to hepatic microsomal phospholipid changes were studied during experimental extrahepatic cholestasis. This study included two groups of Wistar rats: 1) normal rats and 2) cholestatic rats. UDP-Glucuronyltransferase activity (UDP-GT) towards acetaminophen resulted increased in 38

(p < 0.05) in the cholestatic group when compared to normal rats. We also found important changes in hepatocyte microsomal phospholipid profile. When phosphatidylcholine fatty acid composition was analysed, all of them resulted diminished except for an increment on oleic acid content (36

). This fatty acid increase in the main membrane phospholipid had a parallel behaviour with acetaminophen glucuronidation activity. This fact could support an activation role for oleic acid over this enzymic system.

Estudio comparativo de las alteraciones de la hemostasia entre la hepatitis viral aguda fulminante y la cirrosis terminal. / Comparative study of hemostatic changes in acute viral hepatitis and terminal cirrhosis

Se presentan veinte enfermos con dano hepatico grave, todos de evolucion fatal, en quienes se analizan los parametros de hemostasia. Once padecieron hepatitis viral aguda fulminante (HVF) nueve padecieron de cirrosis hepatica. Los factores de coagulacion aqui estudiados exteriorizan el dano del parenquima hepatico. La diferencia mas importante entre ambas patologias, se evidencio en mayor alteracion de los factores II, V, VII-X, en HVF que en cirrosis A pesar de ello, el numero de pacientes que presentaron hemorragia, fue similar para ambos grupos. El tiempo de Quick y del KPTT, se complementan en el diagnostico de ambas patologias