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Objective To evaluate the efficacy and safety of 0.03% tacrolimus ointment for the treatment of atopic dermatitis (AD) in Chinese children. Methods A total of 139 children, 2 to17 years of age, with moderate to severe AD from 5 study centres were enrolled in this multicentre, randomized, double-blind, vehicle-controlled, parallel group study. Treatment with 0.03% tacrolimus ointment or vehicle was applied twice daily to the affected areas for 3 weeks. Visits were scheduled on day 1 (base line, before treatment) and 1, 2, 3 weeks after the treatment. The main therapeutic parameter was the efficacy rate at the end of the treatment. Results The efficacy rates were 84.6% and 29.0% for tacrolimus group and vehicle group, respectively (P
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AIM: To study the adverse reactions of hydroxychloroquine (HCQ) in ophthalmology. METHODS: Thirty-nine patients treated with HCQ for more than six months were performed ophthalmic examinations including some specifie retinal function tests. RESULTS: There were 3 patients (8%) who presented the visual fields was minified. The visual acuity of one patient was decreased. The cumulative doses of HCQ were more than 100 g in this three patients. CONCLUSION: The adverse reactions of HCQ in ophthalmology are related with the cumulative doses of HCQ. The expression is that the visual fields and visual acuity are decreased.
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Objective To explore whether the Kang Kefei and Tian Runmei′s diagnostic criteria (K-T criteria) is suitable for atopic dermatitis(AD). Methods 917 AD patients, whose diagnosis had been made with the Hanifin and Rajka criteria (H-R criteria) previously, were redignosed by K-T criteria. Their atopic history, and clinical fealures were analysed, too. Results 888 out of 917 patients(96.84%) were consistent with K-T criteria.763 patients (83.21%) had personal or family atopic history. The frequency of facial dermatitis was higher in infantile AD group than that in childhood AD group, adolescence AD group, and adult group. Whereas,the frequency of xerosis,ichthyosis,keratosis pilaris and orbital darkening was lower in infantile AD group than those in other groups. Conclusion Atopic history is an important factor in the diagnosisof AD. K-T criteria is practical and of value in the diagnosis of AD.