ABSTRACT
The prevalence of anemia in India is still unacceptably high at 53.1 % in non-pregnant women, 50.3% in pregnant women, 58.4% in children 6 months and 22.7% in adult men(1) and remains a major public health problem. For screening, tracking as well as monitoring the progress of anemia in both in primary and community health care for public health programs, hemoglobin needs to be estimated accurately.
ABSTRACT
Plants adopt various strategies to fulfill their nitrogen nutrition requirement, the most important being the uptake of nitrate from the soil and its subsequent assimilation in to amino acids. The uptake of nitrate is energy dependent and is an active process involving high affinity and low affinity transport systems. The net uptake of the anion depends upon both influx as well as on its passive efflux. When the uptake far exceeds over its assimilation in the plant, there is considerable accumulation of nitrate in the plant parts making them unfit for human and cattle consumption. Various environmental factors affect the uptake and accumulation of nitrate, which along with the genetic component of the plant affecting the net uptake and accumulation of the nitrate, need to be considered and carefully manipulated for effective nitrogen management in the plant, soil and aquatic environment.
Subject(s)
Environment , Nitrates/metabolism , Plants/metabolismABSTRACT
The molecular basis of the sunlight-induced skin carcinogenesis has been elucidated. Of the two ultraviolet components of sunlight that reach the earth's surface the UV-B is known to be carcinogenic but the mode of action of UV-A, the predominant component of sunlight, is ill understood. Using the liposomes as a model system, it has been shown here that UV-A causes dose-dependent lipid peroxidation as estimated by measurements of conjugated dienes, lipid hydroperoxides, malondialdehydes and the fluorescent adducts (Schiff bases) produced by the reaction of MDA with glycine. Direct exposure to sunlight has also been shown to cause dose-dependent lipid peroxidation. The UV-A induced lipid peroxidation has also been shown to be dependent on dose rate. While the sodium formate, dimethyl sulphoxide, superoxide dismutase and EDTA do not have any significant effect, sodium azide, histidine, beta-carotene and dimethylfuran were shown to inhibit significantly the UV-A induced lipid peroxidation, thereby providing significant evidence of the involvement of singlet oxygen (1O2) as the initiating agent. The use of D2O in place of H2O as the liposome dispersing medium enhanced to great extent the UV-A induced lipid peroxidation, thereby lending additional support to the finding that singlet oxygen was the initiating agent. The possible mode of formation of 1O2 on exposure to UV-A was discussed. This study also highlighted the role of environmental factors on the sunlight-induced cutaneous damage. Finally, the relation between lipid peroxidation, DNA damage and carcinogenesis has been discussed in a way to suggest the possible link between sunlight exposure and causation of skin cancer.
Subject(s)
Humans , Lipid Peroxidation/radiation effects , Liposomes , Models, Biological , Neoplasms, Radiation-Induced/etiology , Skin Neoplasms/etiology , Sunlight/adverse effects , Ultraviolet Rays/adverse effectsABSTRACT
Familial scleroderma is rare. There have been few reported cases of familial scleroderma in medical literature. This report adds one more instance to the literature. Two members in one family had clinically and histologically established localised scleroderma (morphea). The hereditary aspect of the disease has not been well established. But this instance along with the previous documented instance suggest that genetic factor may play a role in the etiopathogenesis of the disease.