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1.
An. bras. dermatol ; 96(6): 655-671, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1355628

ABSTRACT

Abstract The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, skin as an organ, goes beyond its protective and barrier functions, as it provides clues for the identification of some systemic diseases. The dermatologist then raises diagnostic hypotheses for conditions related to all systems and refers them to the appropriate specialty. With easy access to examination by trained eyes and biopsies, the skin can present specific or non specific alterations on histopathology. In the first case this combination establishes the diagnosis of the disease itself. Non specific manifestations can occur in a variety of contexts and then histopathology is not specific of a particular disease. This article is divided into two parts that will cover large groups of diseases. In this first part, cutaneous manifestations of the main rheumatologic diseases are described, which are the ones with the greatest interface with dermatology. The authors also talk about vascular manifestations and granulomatous diseases. In the second part, endocrinological, hematological, oncological, cardiovascular, renal, gastrointestinal diseases, pruritus and its causes are discussed, and finally, the dermatological manifestations of SARS-CoV-2 coronavirus infection. The authors' intention is that, by using direct and easily accessible language, aim to provide practical material for consultation and improvement to all dermatologists who recognize the importance of a comprehensive assessment of their patients.


Subject(s)
Humans , Skin Diseases/etiology , Skin Diseases/diagnostic imaging , Collagen Diseases , COVID-19 , SARS-CoV-2
3.
An. bras. dermatol ; 94(2,supl.1): 76-107, Mar.-Apr. 2019. tab, graf
Article in English | LILACS | ID: biblio-1011088

ABSTRACT

Abstract: Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially involving the knees, elbows, scalp and genitals. Besides the impact on the quality of life, the systemic nature of the disease makes psoriasis an independent risk factor for cardiovascular disease, especially in young patients with severe disease. By an initiative of the Brazilian Society of Dermatology, dermatologists with renowned clinical experience in the management of psoriasis were invited to form a work group that, in a partnership with the Brazilian Medical Association, dedicated themselves to create the Plaque Psoriasis Diagnostic and Treatment Guidelines. The relevant issues for the diagnosis (evaluation of severity and comorbidities) and treatment of plaque psoriasis were defined. The issues generated a search strategy in the Medline-PubMed database up to July 2018. Subsequently, the answers to the questions of the recommendations were devised, and each reference selected presented the respective level of recommendation and strength of scientific evidence. The final recommendations for making up the final text were worded by the coordinators.


Subject(s)
Humans , Male , Female , Psoriasis/diagnosis , Psoriasis/therapy , Phototherapy/methods , Psoriasis/epidemiology , Societies, Medical , Time Factors , Vitamin D/analysis , Severity of Illness Index , Brazil , Comorbidity , Anthralin/therapeutic use , Methotrexate/therapeutic use , Cyclosporine/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Dermatologic Agents/therapeutic use , Dermatology , Drug Combinations , Calcineurin Inhibitors/therapeutic use , Antibodies, Monoclonal/therapeutic use
4.
An. bras. dermatol ; 92(6): 826-829, Nov.-Dec. 2017. tab
Article in English | LILACS | ID: biblio-887130

ABSTRACT

Abstract: Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.


Subject(s)
Humans , Psoriasis/complications , Psoriasis/pathology , Intercellular Adhesion Molecule-1/analysis , Capillary Leak Syndrome/etiology , Capillary Leak Syndrome/pathology , Vascular Endothelial Growth Factor A/analysis , Psoriasis/physiopathology , Cytokines/analysis , Capillary Leak Syndrome/physiopathology
5.
An. bras. dermatol ; 91(4): 534-536, July-Aug. 2016. graf
Article in English | LILACS | ID: lil-792449

ABSTRACT

Abstract: Lichen sclerosus is an uncommon inflammatory dermatosis with preferential involvement of the urogenital region. The extragenital involvement is uncommon and is characterized by small rounded macules or papules, pearly white in color. The coexistence of lichen sclerosus and scleroderma plaques in most cases with extragenital location has been reported in the literature. We report a case of lichen sclerosus associated with scleroderma in children, highlighting the importance of dermoscopy in diagnosis.


Subject(s)
Humans , Female , Child , Scleroderma, Localized/pathology , Scleroderma, Localized/diagnostic imaging , Lichen Sclerosus et Atrophicus/pathology , Lichen Sclerosus et Atrophicus/diagnostic imaging , Dermoscopy/methods , Scleroderma, Localized/complications , Skin/pathology , Skin/diagnostic imaging , Lichen Sclerosus et Atrophicus/complications , Erythema/pathology , Erythema/diagnostic imaging
6.
An. bras. dermatol ; 88(6,supl.1): 197-199, Nov-Dec/2013. graf
Article in English | LILACS | ID: lil-696796

ABSTRACT

The antagonists of tumor necrosis factor alpha (TNF-α) are increasingly being used in the treatment of inflammatory and autoimmune diseases. Several adverse effects of these drugs have been reported, including the paradoxical development of sarcoidosis, especially with the use of etanercept. We present the first Brazilian case report of systemic sarcoidosis induced by etanercept and a literature review.


Os medicamentos antagonistas do fator de necrose tumoral alfa (TNF-α) estão sendo cada vez mais utilizados no tratamento de doenças inflamatórias e autoimunes. Efeitos adversos desses medicamentos vem sendo relatados, incluindo o desenvolvimento paradoxal de sarcoidose, principalmente com o uso do etanercepte. Apresentamos o primeiro relato de caso brasileiro de sarcoidose sistêmica induzida por etanercepte e uma revisão da literatura.


Subject(s)
Female , Humans , Middle Aged , Antirheumatic Agents/adverse effects , Immunoglobulin G/adverse effects , Sarcoidosis/chemically induced , Skin Diseases/chemically induced , Arthritis, Rheumatoid/drug therapy , Brazil , Receptors, Tumor Necrosis Factor , Sarcoidosis/pathology , Skin Diseases/pathology , Tumor Necrosis Factor-alpha/antagonists & inhibitors
7.
An. bras. dermatol ; 87(1): 139-141, Jan.-Feb. 2012. ilus, tab
Article in English | LILACS | ID: lil-622464

ABSTRACT

Psoriasis is a chronic inflammatory disease that can affect skin and joints. Their treatment varies depending on the severity and includes topical and systemic. Among the latter are the immunobiological that target the T cell We report a case that demonstrates the close relationship between psoriasis, lymphoma and biologic therapies.


A psoríase é uma doença inflamatória crônica que pode afetar a pele e as articulações. Seu tratamento varia conforme a gravidade e inclui medicamentos tópicos e sistêmicos. Dentre os últimos estão os imunobiológicos, que têm como alvo a célula T. Relatamos um caso que demonstra a estreita relação entre a psoríase, o linfoma e os imunobiológicos.


Subject(s)
Adult , Female , Humans , Immunoglobulin G/adverse effects , Immunosuppressive Agents/adverse effects , Lymphoma/etiology , Psoriasis/drug therapy , Psoriasis/complications , Receptors, Tumor Necrosis Factor , Skin Neoplasms/etiology
8.
An. bras. dermatol ; 86(4): 797-798, jul.-ago. 2011. ilus
Article in Portuguese | LILACS | ID: lil-600630

ABSTRACT

Relata-se o caso de um homem de 45 anos com dermatofitose superficial de longa data, tratado, inadvertidamente, com corticoide e antibiótico, com progressão subsequente para a forma profunda, conhecida como granuloma de Majocchi. O tratamento com terbinafina VO foi curativo.


We report the case of a man of 45 with superficial dermatophytosis longtime inadvertently treated with antibiotics and corticosteroids with subsequent progression to the deep form, known as granuloma Majocchi. Treatment with orally terbinafine was successful.


Subject(s)
Humans , Male , Middle Aged , Granuloma/pathology , Tinea/pathology , Antifungal Agents/therapeutic use , Granuloma/drug therapy , Naphthalenes/therapeutic use , Tinea/drug therapy
9.
An. bras. dermatol ; 86(3): 593-595, maio-jun. 2011. ilus
Article in Portuguese | LILACS | ID: lil-592162

ABSTRACT

A síndrome de extravasamento capilar sistêmico é rara e causada por aumento da permeabilidade capilar. Várias etiologias estão envolvidas. No nosso serviço de Dermatologia, a principal é a psoríase instável. Diversos tratamentos são usados e muitos ainda estão em estudo. Nosso objetivo foi apresentar esta situação clínica potencialmente fatal que ocorre em nossa especialidade.


The systemic capillary leak syndrome is rare and caused by increased capillary permeability. Several etiologies are involved. In our Department of Dermatology the main one is unstable psoriasis. Several treatments are used and many are still under study. Our objective was to present this potentially fatal medical condition that occurs in our specialty.


Subject(s)
Humans , Capillary Leak Syndrome , Capillary Leak Syndrome/complications , Capillary Leak Syndrome/etiology , Capillary Leak Syndrome/pathology , Prognosis
10.
An. bras. dermatol ; 86(1): 125-127, jan.-fev. 2011. ilus
Article in Portuguese | LILACS | ID: lil-578317

ABSTRACT

O Angioma em tufo é considerado um raro tumor vascular cutâneo adquirido. Caracteriza-se por máculas purpúrico-violáceas, dolorosas que podem evoluir para placas com pápulas angiomatosas. Tem natureza benigna, mas o envolvimento extenso é comum, gerando alteração funcional do membro afetado em caso de dor. Os autores relatam um caso de angioma em tufo associado à síndrome dolorosa miofascial, em que o elemento predisponente foi a presença deste tumor desde a infância. A dor local prejudicou a utilização da musculatura e possibilitou o surgimento da síndrome relatada. A realização de bloqueio anestésico de pontos-gatilhos no membro afetado, levou à melhora total dos sintomas.


Tufted angioma is a rare acquired vascular tumor. It is characterized by painful purplish macules that may progress to plaques containing angiomatous papules. The condition is benign; however, it often affects extensive areas of the skin, leading to functional disability of the affected limb if painful. The present report describes a case of a tufted angioma associated with myofascial pain syndrome in which the predisposing element was the presence of this tumor since childhood. Pain at the site of the lesion affected muscle use and led to the onset of the associated syndrome. Complete relief from symptoms was achieved by blocking the trigger points of the affected limb with anesthesia.


Subject(s)
Adult , Female , Humans , Young Adult , Hemangioma/complications , Myofascial Pain Syndromes/etiology , Skin Neoplasms/complications , Myofascial Pain Syndromes/physiopathology , Trigger Points/physiopathology
11.
An. bras. dermatol ; 86(1): 135-137, jan.-fev. 2011. ilus
Article in Portuguese | LILACS | ID: lil-578320

ABSTRACT

Relatamos um caso de higroma cístico na face de uma criança de quatro meses de idade. Havia história de aumento de volume congênito na hemiface direita que involuiu consideravelmente após sinais de infecção. O higroma cístico ou linfangioma é uma malformação congênita rara do sistema linfático, presente ao nascimento em 50 por cento dos casos. Localiza-se preferencialmente na região cervical e na face. Geralmente evolui com crescimento lento e progressivo, podendo comprimir e infiltrar estruturas adjacentes. Sua regressão espontânea ocorre em apenas 6 por cento dos casos.


This report describes the case of a cystic hygroma on the face of a four-month old child. There was a history of congenital swelling of the right hemiface that decreased considerably following signs of infection. The cystic hygroma or lymphangioma is a rare congenital malformation of the lymphatic system that is present at birth in 50 percent of cases. It is usually located on the neck or face. It generally grows slowly and progressively and may compress and infiltrate adjacent structures. Its spontaneous regression occurs in only 6 percent of cases.


Subject(s)
Female , Humans , Infant , Facial Neoplasms/diagnosis , Lymphangioma, Cystic/diagnosis , Neoplasm Regression, Spontaneous , Lymphatic System/abnormalities , Remission, Spontaneous , Tomography, X-Ray Computed
12.
An. bras. dermatol ; 85(5): 705-707, set.-out. 2010. ilus
Article in Portuguese | LILACS | ID: lil-567835

ABSTRACT

O pseudoxantoma elástico perfurante periumbilical (PEPP), ou elastose cálcica perfurante, é distúrbio raro e sua patogênese está associada a alteração da fibra elástica, tendo o trauma provável participação. Apresenta-se caso de paciente de 70 anos com quadro de máculas enegrecidas e pápulas encimadas por crostas na região periareolar e periumbilical há mais de dez anos. O exame histopatológico revelou fibras elásticas alteradas, repletas de cálcio, e formação de pertuito na derme com fibras elásticas degradadas no seu interior. O caso descrito corresponde ao PEPP, que nesta paciente também acomete área periareolar bilateralmente.


The periumbilical perforating pseudoxanthoma elasticum or perforating calcific elastosis is a rare disorder and its pathogenesis is associated with the alteration of elastic fibers, which may probably result from trauma. We present the case of a 70-year-old woman with long-time blackish maculas and keratotic surface papules on the periareolar and periumbilical regions. The histopathological examination revealed altered elastic fibers, replete with calcium and formation of a path in the dermis with elastic fibers degraded in their interior, confirming the clinical diagnosis.


Subject(s)
Aged , Female , Humans , Nipples/pathology , Pseudoxanthoma Elasticum/pathology , Umbilicus/pathology , Breast Diseases/pathology
13.
An. bras. dermatol ; 85(3): 393-395, jun. 2010. ilus
Article in English, Portuguese | LILACS | ID: lil-553052

ABSTRACT

A calcinose idiopática é uma doença rara, caracterizada pelo depósito de sais de cálcio na derme. Possui diversas apresentações clínicas. Em pacientes com Síndrome de Down, ocorre uma rara associação com lesões de calcinose diopática semelhantes a milium.


Idiopathic calcinosis is a rare disease characterized by abnormal deposit of calcium salts on the dermis. It has several clinical presentations. In patients suffering from Down Syndrome, there is a rare association with idiopathic calcinosis lesions similar to milium.


Subject(s)
Child, Preschool , Female , Humans , Calcinosis/pathology , Skin Diseases/pathology
14.
An. bras. dermatol ; 85(1): 9-22, jan.-fev. 2010. ilus
Article in Portuguese | LILACS | ID: lil-546148

ABSTRACT

Os imunossupressores são drogas que agem na divisão celular e têm propriedades anti-inflamatórias. Sendo assim, são essencialmente prescritos na prevenção de rejeição de transplantes e no tratamento das doenças autoimunes e inflamatórias crônicas, que, na Dermatologia, têm a psoríase como maior representante. Nesta sessão serão descritas as principais drogas imunossupressoras, com orientações para seu manejo adequado.


Immunosupressants are drugs that act in cell division and have anti-inflammatory effects. Therefore, they are essentially prescribed in the prevention of transplant rejection and in the treatment of autoimmune disorders and chronic inflammatory diseases, whose main example in Dermatology is psoriasis. In this work the most important immunosuppressive drugs and orientation to properly administer them are going to be described.


Subject(s)
Humans , Immunosuppressive Agents/therapeutic use , Skin Diseases/drug therapy , Azathioprine/therapeutic use , Cyclophosphamide/therapeutic use , Cyclosporine/therapeutic use , Methotrexate/therapeutic use , Mycophenolic Acid/analogs & derivatives , Mycophenolic Acid/therapeutic use
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