ABSTRACT
Eosinophilic gastroenteritis is a rare disease of unknown etiology characterized by eosinophilic infiltration of bowel wall to a variable depth. A 38 year old female presented with loose stool and vomiting since 3 days. She gave history of pain abdomen and weight loss since six months. Barium study revealed ascending colon stricture just proximal to the hepatic flexure ? malignant. A colonic biopsy was done, which was reported as edematous colonic mucosa with mild increase in eosinophils. Intra-operatively, a dense long segment stricture was found in the ascending colon extending to the caecum which warranted a right hemicolectomy. Histopathology revealed dense infiltration of eosinophils in the entire thickness of ileal and caecal wall. The diagnosis of eosinophilic gastroenteritis was made. Patient responded well to steroids. The case is being reported to highlight its rarity due to caecal involvement, presentation as intestinal obstruction and missed diagnosis on endoscopic biopsy.
Subject(s)
Adult , Enteritis/complications , Enteritis/drug therapy , Eosinophilia/complications , Female , Gastritis/complications , Gastritis/drug therapy , Humans , Intestinal Obstruction/drug therapy , Intestinal Obstruction/epidemiology , Intestinal Obstruction/etiology , Intestine, Small/drug therapyABSTRACT
Background: Mast cells are found in tissues throughout body, particularly in proximity to surfaces that interface with the external environment. They are found at all levels of dermis, where they are grouped around blood vessels, nerves and appendages. Increase in mast cell number have been reported in various cutaneous diseases. Aims: We aim to identify and analyse the morphological aspects of distribution of mast cells and their value in non-neoplastic skin lesions. Material and Methods: Ninety seven biopsies of various skin lesions were studied for mast cells by Toluidine Blue at pH 3.9. Result: All the skin lesions showed significant increase in mast cell number. Psoriasis showed maximum number of mast cells (127/mm2) followed by Lichen planus (108/mm2). Among the cases of cutaneous bacterial infections, mast cells were maximum in leprosy cases (99/mm2) and lowest in cutaneous tuberculosis. A comparative decrease in number of mast cells was seen from lepromatous leprosy to tuberculoid leprosy. A wide range of morphological alterations of mast cells were observed in these skin lesions. Psoriasis and bullous pemphigoid cases showed maximum spindle cell morphology. Conclusion: Tissue mast cell number, distribution and morphology vary in different skin lesions depending on the degree of mast cell activation. This may have a bearing on diagnosis and management.
Subject(s)
Cell Count , Humans , Leprosy, Lepromatous/pathology , Lupus Vulgaris/pathology , Mast Cells/pathology , Psoriasis/pathology , Skin Diseases/pathology , Staining and Labeling , Tolonium ChlorideSubject(s)
Biopsy , Biopsy, Fine-Needle , Breast Neoplasms/diagnosis , Breast Neoplasms/pathology , Breast Neoplasms/secondary , Carcinoma/diagnosis , Carcinoma/pathology , Carcinoma/secondary , Female , Herpes Zoster/diagnosis , Herpes Zoster/pathology , Histocytochemistry , Humans , Middle Aged , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Skin Neoplasms/secondaryABSTRACT
An unusual combination of two benign breast neoplasms adenomyoepithelioma and phyllodes tumor presenting as a solitary breast lump have been described. Both these tumors have tendencies to recur and have malignant potential. This patient also presented with a recurrent breast neoplasm. The case is reported for its rarity.
Subject(s)
Adenomyoma/pathology , Breast Neoplasms/pathology , Female , Humans , Middle Aged , Myoepithelioma/pathology , Neoplasm Recurrence, Local/pathology , Neoplasms, Multiple Primary/pathology , Phyllodes Tumor/pathologyABSTRACT
Six cases of tumoral calcinosis detected in a short period of time are reported. All the cases were in late adults and mostly in females. Most lesions were in inactive late stage. Available published literature on this rare interesting lesion has been reviewed. The etiopathogenesis and pathological features are discussed. It appears that the strict compartmentalization of lesions into different stages depending on the histological features and the importance of proliferating areas as a marker for progression and recurrence has been over emphasized.
Subject(s)
Aged , Calcinosis/diagnosis , Calcium/blood , Female , Humans , India , Male , Middle Aged , Phosphates/bloodABSTRACT
Pulmonary placental transmogrification (PPT), a rare cystic lesion of the lung is described in a 38-year-old male who had no risk factor for emphysema. The lesion was characterised by large bullae with its inner configuration resembling placental chorionic villi macroscopically and merging imperceptibly with adjacent normal lung tissue. To the best of our knowledge, this is the first case report from India and South Asia. Awareness of this rare entity helps make a definite diagnosis. Surgery alone is curative and not conservative management as prescribed for emphysema.