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Objective To study the operation approach and operation method for giant dumbbell neurogenic tumors of the posterior mediastinum,and summarize the experience ofthoracoscopic surgery via posterior midline approach in tumor resection.Methods The clinical data of 11 patients with posterior mediastinum dumbbell tumor,admitted to our hospital from February 2003 to May 2013,were analyzed retrospectively.Traditional posterolateral incision combined with thoracic tumor resection was performed in the 7 patients of control group;and thoracic laminectomy combined with intraspinal tumor mass resection was performed in the 4 patients of treatment group.Results The operation went smoothly.Patients in the treatment group accepted no auxiliary incision or conversion to thoracotomy,without occurrence of dysneuria and cerebrospinal fluid leakage and other serious complications.As compared with the control group,the treatment group had smaller volume of bleeding,shorter chest drainage time and hospital stays,and longer operation time.Postoperative pathology implied 8 neurofibromas and 3 schwannomas.No dysneuria or recurrence was found during the follow-up of 12-36 months.Conclusion Double-hole thoracoscopic surgery via posterior midline approach is a safe,effective,minimally invasive method in the treatment of dumbbell neurogenic tumors of the posterior mediastinum.
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Objective To determine the changes of patients with severe pulmonary contusion and the relationship among the serum level of alpha-granular membrane protein (CD62p), the severity of injury and prognosis. Methods The serum level of CD62p, was measured in 45 patients with severe pulmonary contusion on hour 2, hour 12,day 1,3,7 after injured. Forty-five patients were divided into two groups: the survive group and the death group. The levels of CD62p between two groups were compared. Results The serum levels of CD62p in patients with severe pulmonary contusion on 12 hours, 1,3 days after injury were higher than those on 2 hours (P<0.05). The serum levels of CD62p in the survive group and death group on 2 h, 12 hours after injury were higher than those in the control group(P<0.05), and the serum levels of CD62p in the death group were higher than those in the survive group. Conclusion It was helpful in judging the severity of head in jury and prognosis to determine the serum levels of CD62p in patients with severe pulmonary contusion.
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Objective To explore the relationship between the expression of basic fibroblast growth factor (bFGF) and microvessel density(MVD)in non-small cell lung cancer.Methods The expression of bFGF and MVD were observed in 54 eases of NSCLC were detected with in situ hybrldization and immunohistochemical detection.Resuits The expression of bFGF and MVD was greater in adenecarcinomas than in squamous cell carcinomas of NSCLC (P＜0.05).The expression of bFGF was significantly different among the three groups of both squamous cell carcinomas and adenocarecnomas with varying differentiation (P＜0.05).There was hisher bFGF expression and greater MVD in NSCLC patients with regional lymplmode involvement and those with laterdistant metastasis(P＜0.05).Condusion bFGF may play an important role in tumor angiogenesis and lymphatic metastasis of human NSCLC,and detection of bFGF may be a good metastasis and prognostic predictors for human NSCLC.
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Objective To discuss the diagnosis and treatment of pulmonary contusion. Methods A retrospective study was carried out in 132 cases of severe pulmonary contusion (injury severity score ≥20) from February 1993 to December 2003. Results Of all, 107 cases (81.1%)survived and 25 (18.9%)died. Conclusions Chest X-ray and CT are reliable for the diagnosis of pulmonary contusion. The important methods include keeping airway clear, progressively treating shock and reasonably applying ventilation, steroids as well as antibiotics. The early diagnosis and the prompt treatment of the associated injuries are key to higher cure rate.