ABSTRACT
Objective To study the diagnostic and distinguishing diagnostic value in primary hepatic carcinoma (PHC)and metastatic hepatic carcinoma (MHC)by the serum sialic acid (SA)detection.Methods During January 2012 to June 2014, 100 cases of patients with PHC,91 cases of patients with MHC,155 cases of benign liver disease patients,and 139 healthy people in Wuyi Traditional Chinese Medicine Hospital were included into the study.The concentration of serum SA and AFP were detected by chemical enzymatic method and chemiluminescence method,SPSS1 9.0 was used to analysis the results.Re-sults The concentration of serum SA in PHC patients (701.08±189.33 mg/L)were significantly higher than benign liver disease patients (588.38±98.51 mg/L)and healthy people (572.37±89.13 mg/L),there was statistical significance (P=0.000),the significantly statistical differences were also in MHC (790.20±162.29 mg/L)and PHC patients (P=0.027). Serum SA in the diagnosis of MHC sensitivity,specificity and AUC were 84.6%,85.2% and 0.895,compared with serum AFP (sensitivity 22.2%,specificity 29.6% and AUC 0.301)had statistically significance (P=0.000).Conclusion The se-rum SA has important clinical significance in the diagnosis and distinguishing diagnosis of PHC and MHC.
ABSTRACT
Objective To study the levels of serum homocysteine(Hcy) ,high-sensitivity C-reactive protein (hs-CRP) and blood lipid and their correlation in the different age stage patients with cerebral infarction .Methods 352 patients with cerebral infarction receiving treatment in the hospital from December 2011 to November 2013 were selected as the study subjects and divided into the youth group ,middle age group and elderly group by age ,with contemporaneous 134 healthy individuals of physical examination as the control group .Serum lipids ,hs-CRP ,Hcy levels and the rate of abnormal test results were compared among 4 groups and the bi-variate correlation analysis was performed .Results The serum hs-CRP ,Hcy levels in the youth group were higher than those in the control group ,while the high density lipoprotein cholesterol(HDL-C) level was lower than tha tin the control group ,the difference was statistically significant (P<0 .05) .The serum low density lipoprotein cholesterol(LDL-C) ,total cholesterol (TC) ,hs-CRP and Hcy levels in the middle age and the elderly groups were significantly higher than those in the control group ,while the HDL-C level was significantly lower than that in the control group ,the difference was statistically significant (P<0 .05) .The abnormal rates of HDL-C ,hs-CRP and Hcy test results in the youth ,middle and elderly groups were significantly higher than those in the control group with statistical difference (P< 0 .05) .The abnormal rates of LDL-C detection results in the middle age group and elderly group were significantly higher than that in the control group ,the difference was statistically significant (P<0 .05) .Hcy ,hs-CRP and lipid in the youth group ,middle group and elderly group had no significant correlation ;HDL-C was negatively correlated with hs-CRP (P<0 .05);TC was positively correlated with LDL-C ,HDL-C and triglyceride(P<0 .05) .Conclusion Hyperhomocys-teinemia is an independent risk factor for cerebral infarction occurrence ,has no significant correlation with blood lipid and hs-CRP levels ,and can be used as a reliable indicator of the disease condition monitoring .