Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 170
Filter
1.
Annals of Dermatology ; : 335-343, 2016.
Article in English | WPRIM | ID: wpr-105047

ABSTRACT

BACKGROUND: Hand eczema is one of the most common skin disorders and negatively affects quality of life. However, a large-scale multicenter study investigating the clinical features of patients with hand eczema has not yet been conducted in Korea. OBJECTIVE: To identify the prevalence of various hand diseases, which is defined as all cutaneous disease occurring in hands, and to investigate the clinical features of patients with hand eczema and the awareness about hand eczema in the general population and to compare the prevalence of hand eczema between health care providers and non-health care providers. METHODS: To estimate the prevalence of hand diseases, we analyzed the medical records of patients from 24 medical centers. Patients were assessed by online and offline questionnaires. A 1,000 from general population and 913 hand eczema patients answered the questionnaire, for a total of 1,913 subjects. RESULTS: The most common hand disease was irritant contact dermatitis. In an online survey, the lifetime prevalence of hand eczema was 31.2%. Hand eczema was more likely to occur in females (66.0%) and younger (20~39 years, 53.9%). Health care providers and housewives were the occupations most frequently associated with hand eczema. Winter (33.6%) was the most common season which people experienced aggravation. The 63.0% and 67.0% answered that hand eczema hinders their personal relationship and negatively affects daily living activities, respectively. CONCLUSION: Hand eczema is a very common disease and hinders the quality of life. The appropriate identification of hand eczema is necessary to implement effective and efficient treatment.


Subject(s)
Female , Humans , Activities of Daily Living , Dermatitis, Contact , Eczema , Hand , Health Personnel , Korea , Medical Records , Occupations , Prevalence , Quality of Life , Seasons , Skin , Surveys and Questionnaires
2.
Annals of Dermatology ; : 35-42, 2014.
Article in English | WPRIM | ID: wpr-48648

ABSTRACT

BACKGROUND: Hardening phenomenon of human skin after repeated exposure to the irritants is well-known, but the precise mechanism remains elusive. OBJECTIVE: To modify the previous experimental model of hardening phenomenon by repeated applications of two different concentrations of sodium lauryl sulfate (SLS) solutions to Korean healthy volunteers and to investigate the quantitative changes of ceramides in stratum corneum before and after chronic repeated irritation. METHODS: Eight hundred microliters of distilled water containing 0.1% and 2% SLS was applied for 10 minutes on the forearm of 41 healthy volunteers for 3 weeks. After an intervening 3-week rest, 24-hour patch tests with 1% SLS were conducted on previously irritated sites. Transepidermal water loss (TEWL), erythema index and quantity of ceramide were measured in the stratum corneum before and after irritation. RESULTS: TEWL values on the sites preirritated with 2% SLS were lower than those with 0.1% SLS. Hardening phenomenon occurred in 24 volunteers at day 44. The changes in ceramide levels were not significantly higher in the hardened skin than in the non-hardened skin. CONCLUSION: Repetitive stimulation with a higher concentration of SLS can more easily trigger skin hardening.


Subject(s)
Humans , Ceramides , Erythema , Forearm , Healthy Volunteers , Irritants , Models, Theoretical , Patch Tests , Skin , Sodium Dodecyl Sulfate , Volunteers , Water
3.
Annals of Dermatology ; : 189-195, 2013.
Article in English | WPRIM | ID: wpr-148971

ABSTRACT

BACKGROUND: Chronic idiopathic urticaria (CIU) is considered a complex and multifactorial disease. Excessive histamine intake may induce an attack of urticaria. The main enzyme for histamine metabolism is diamine oxidase (DAO). OBJECTIVE: Plasma histamine concentrations and DAO activities were evaluated to determine whether there are abnormalities in the histamine metabolism of CIU patients. METHODS: Seventy-five CIU patients and twenty-five healthy control subjects were included in the study. Blood was taken from all subjects to measure plasma levels of the histamine and DAO. RESULTS: Mean plasma histamine levels were significantly higher in CIU patients (11.59+/-10.98 nM) than in the control subjects (8.75+/-2.55 nM) (p=0.04). Mean DAO activities were lower in patients of CIU (80.86+/-26.81 histamine degrading unit [HDU]/ml) than in the controls (81.60+/-9.67 HDU/ml), but without significant difference. In 15 CIU patients with gastrointestinal symptoms, the mean histamine concentration was higher (12.43+/-7.97 nM) and DAO activity was lower (77.93+/-27.53 HDU/ml) than in the remaining 60 CIU patients without gastrointestinal symptoms (11.38+/-11.67 nM and 81.58+/-26.82 HDU/ml), without significant difference. The relationship between DAO activity and plasma histamine concentrations showed a significant negative linear value (p=0.001). There were no significant relationships between plasma histamine concentrations and symptom severity score. CONCLUSION: In CIU patients, a high plasma histamine concentration may not be explained by DAO activity. CIU patients with gastrointestinal (GI) symptoms showed no significantly lower DAO activity. Larger group studies are required to elucidate the relationship between plasma histamine concentrations and DAO activity, especially of CIU patients with GI symptomsto understand the difference in CIU patients with and without GI symptoms.


Subject(s)
Humans , Amine Oxidase (Copper-Containing) , Histamine , Plasma , Urticaria
4.
Annals of Dermatology ; : 196-202, 2013.
Article in English | WPRIM | ID: wpr-148970

ABSTRACT

BACKGROUND: It is well known that atopic dermatitis (AD) is related to food hypersensitivity, although its prevalence varies among several studies according to age group, severity, country, survey time, and test method. OBJECTIVE: To examine the prevalence and status of food hypersensitivity among childhood AD patients in Korea. METHODS: A total of 95 patients were enrolled in the study. The history of food hypersensitivity was collected by interviews. The severity of AD was evaluated by eczema area and severity index (EASI). We took blood samples to measure serum total and food-specific immunoglobulin E (IgE) levels. Based on the histories and serum IgE levels, open oral food challenge (OFC) testing was performed to confirm food hypersensitivity. RESULTS: Forty-two (44.2%) of the 95 AD patients had histories of food hypersensitivity. They reported that the most common suspicious foods were egg (n=13, 13.7%), pork (n=9, 9.5%) and cow milk (n=8, 8.4%). The mean EASI score was 16.05+/-9.76. Thirty-nine (41.1%) of the 95 patients showed elevated serum food-specific IgE levels. The specific IgE levels were elevated for egg (n=17, 17.9%), milk (n=12, 12.6%), peanut (n=10, 10.5%) and wheat (n=8, 8.4%). Fifty-one (53.8%) of 95 patients underwent open OFC, and only 7 (13.7%) of these patients showed positive reactions. CONCLUSION: The overall prevalence of food hypersensitivity in patients with childhood AD in Korea was 8.3% (7/84). The most common foods causing food hypersensitivity were egg and milk. Among the foods causing hypersensitivity, AD patients in Korea often underestimated peanut, while they overestimated pork.


Subject(s)
Humans , Dermatitis, Atopic , Eczema , Food Hypersensitivity , Hypersensitivity , Immunoglobulin E , Immunoglobulins , Korea , Milk , Ovum , Prevalence , Triticum
5.
Annals of Dermatology ; : 285-291, 2013.
Article in English | WPRIM | ID: wpr-131890

ABSTRACT

BACKGROUND: Previous clinical trials with evening primrose oil in atopic dermatitis (AD) treatment have shown different results. In addition, the optimal dose and duration of treatment with evening primrose oil have not yet been determined. OBJECTIVE: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids. METHODS: Forty AD patients were enrolled for the study and randomly divided into 2 groups: those who received evening primrose oil 160 mg daily for 8 weeks and those who received 320 mg of evening primrose oil twice daily for 8 weeks. We evaluated the Eczema Area Severity Index (EASI) scores of all AD patients at weeks 0, 2, 4 and 8. In addition, we measured the levels of serum fatty acids, including C16 : 0 (palmitic), C18 : 2n (linoleic), C18 : 3n (linolenic) and C20 : 4 (arachidonic acid) using gas chromatography. RESULTS: The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance. After evening primrose oil treatment, EASI scores were reduced in the 2 groups. The improvement in EASI scores was greater in the 320 mg group than in the 160 mg group. There were no side effects seen in either group during the study in the 2 groups. CONCLUSION: The results of this study suggest that the 320 mg and 160 mg groups may be equally effective in treating AD patients and show dose-dependent effects on serum fatty acid levels and EASI scores.


Subject(s)
Adolescent , Child , Humans , Dermatitis, Atopic , Eczema , Fatty Acids , gamma-Linolenic Acid , Linoleic Acids , Oenothera biennis , Plant Oils
6.
Annals of Dermatology ; : 292-297, 2013.
Article in English | WPRIM | ID: wpr-131888

ABSTRACT

BACKGROUND: Recent epidemiologic studies have shown that environmental contaminants such as air pollution and tobacco smoke play an important role in the pathophysiology of atopic dermatitis (AD). OBJECTIVE: The aim of this study was to evaluate the relationship between the severity of AD and indoor air pollution. METHODS: The study population consisted of 425 children from 9 kindergartens, Korea. The authors surveyed the prevalence of AD and evaluated disease severity by the eczema area and severity index (EASI) score and investigator's global assessment (IGA). After measuring indoor air pollution, a program to improve indoor air quality was conducted in 9 kindergartens. Seven months later, the prevalence and disease severity were evaluated. RESULTS: The initial prevalence of AD was 8% and the mean EASI score was 2.37. The levels of particulate material 10 (PM10) and carbon dioxide (CO2) were higher in some kindergartens compared to the normal values. Subsequent to the completion of the indoor air quality improvement program, the mean PM10 level was significantly decreased from 182.7 to 73.4 microg/m3. After the completion of the program, the prevalence of AD and the mean EASI were decreased, and the changes were both statistically significant. The mean number of hospital visits decreased from 1.3 per month during the first survey to 0.7 per month during the second survey, which was statistically significant. CONCLUSION: Indoor air pollution could be related to AD. The reduction of PM10 through improving indoor air quality should be considered in kindergartens and schools in order to prevent and relieve AD in children.


Subject(s)
Child , Humans , Air Pollutants , Air Pollution , Air Pollution, Indoor , Carbon Dioxide , Dermatitis, Atopic , Eczema , Epidemiologic Studies , Korea , Prevalence , Reference Values , Smoke , Nicotiana
7.
Annals of Dermatology ; : 285-291, 2013.
Article in English | WPRIM | ID: wpr-131887

ABSTRACT

BACKGROUND: Previous clinical trials with evening primrose oil in atopic dermatitis (AD) treatment have shown different results. In addition, the optimal dose and duration of treatment with evening primrose oil have not yet been determined. OBJECTIVE: The aim of this study is to investigate the dose-response treatment effects of evening primrose oil on clinical symptoms of AD and serum concentrations of polyunsaturated fatty acids. METHODS: Forty AD patients were enrolled for the study and randomly divided into 2 groups: those who received evening primrose oil 160 mg daily for 8 weeks and those who received 320 mg of evening primrose oil twice daily for 8 weeks. We evaluated the Eczema Area Severity Index (EASI) scores of all AD patients at weeks 0, 2, 4 and 8. In addition, we measured the levels of serum fatty acids, including C16 : 0 (palmitic), C18 : 2n (linoleic), C18 : 3n (linolenic) and C20 : 4 (arachidonic acid) using gas chromatography. RESULTS: The serum fatty acid levels C18 : 3n and C20 : 4 were higher in the 320 mg group than in the 160 mg group, with statistical significance. After evening primrose oil treatment, EASI scores were reduced in the 2 groups. The improvement in EASI scores was greater in the 320 mg group than in the 160 mg group. There were no side effects seen in either group during the study in the 2 groups. CONCLUSION: The results of this study suggest that the 320 mg and 160 mg groups may be equally effective in treating AD patients and show dose-dependent effects on serum fatty acid levels and EASI scores.


Subject(s)
Adolescent , Child , Humans , Dermatitis, Atopic , Eczema , Fatty Acids , gamma-Linolenic Acid , Linoleic Acids , Oenothera biennis , Plant Oils
8.
Annals of Dermatology ; : 292-297, 2013.
Article in English | WPRIM | ID: wpr-131885

ABSTRACT

BACKGROUND: Recent epidemiologic studies have shown that environmental contaminants such as air pollution and tobacco smoke play an important role in the pathophysiology of atopic dermatitis (AD). OBJECTIVE: The aim of this study was to evaluate the relationship between the severity of AD and indoor air pollution. METHODS: The study population consisted of 425 children from 9 kindergartens, Korea. The authors surveyed the prevalence of AD and evaluated disease severity by the eczema area and severity index (EASI) score and investigator's global assessment (IGA). After measuring indoor air pollution, a program to improve indoor air quality was conducted in 9 kindergartens. Seven months later, the prevalence and disease severity were evaluated. RESULTS: The initial prevalence of AD was 8% and the mean EASI score was 2.37. The levels of particulate material 10 (PM10) and carbon dioxide (CO2) were higher in some kindergartens compared to the normal values. Subsequent to the completion of the indoor air quality improvement program, the mean PM10 level was significantly decreased from 182.7 to 73.4 microg/m3. After the completion of the program, the prevalence of AD and the mean EASI were decreased, and the changes were both statistically significant. The mean number of hospital visits decreased from 1.3 per month during the first survey to 0.7 per month during the second survey, which was statistically significant. CONCLUSION: Indoor air pollution could be related to AD. The reduction of PM10 through improving indoor air quality should be considered in kindergartens and schools in order to prevent and relieve AD in children.


Subject(s)
Child , Humans , Air Pollutants , Air Pollution , Air Pollution, Indoor , Carbon Dioxide , Dermatitis, Atopic , Eczema , Epidemiologic Studies , Korea , Prevalence , Reference Values , Smoke , Nicotiana
9.
Korean Journal of Dermatology ; : 730-733, 2013.
Article in Korean | WPRIM | ID: wpr-91555

ABSTRACT

Oral allergy syndrome (OAS) usually presents as an immediate swelling and itching sensation of the mouth and throat after ingestion of a food allergen. OAS may be the most common food allergy-related manifestation. Watermelon and melon belong to the Cucurbitaceae family and often show allergenic cross reactivity. Profilin is a 13 kda protein that is identified as a relevant pollen allergen in airborne pollen and related plant food allergies. Profilin is found in both watermelon and melon. Here we report a case of OAS to watermelon and melon in an 11 year-old boy. He was positive to the skin prick test, patch test and oral challenge test with watermelon and melon.


Subject(s)
Humans , Citrullus , Cucurbitaceae , Eating , Food Hypersensitivity , Hypersensitivity , Mouth , Patch Tests , Pharynx , Plants , Pollen , Profilins , Pruritus , Sensation , Skin
10.
Korean Journal of Dermatology ; : 806-808, 2013.
Article in Korean | WPRIM | ID: wpr-204073

ABSTRACT

Muscle herniation is defined as a protrusion of a portion of a muscle through a defect of the muscle fascia. The anterior tibialis muscle is the most common site of herniation. This condition is a relatively common complaint among athletes, and it has been frequently reported in the orthopedic surgery literature, whereas it has received little attention in the dermatological literature. Clinical findings include the presence of soft, compressible nodules that vary in size depending on their position. Usually, herniation is asymptomatic and the main concern is cosmetic, but the patient may seek medical treatment because of pain. Here we report a 65-year-old woman who visited our hospital for an evaluation of two asymptomatic nodules that were on her lower legs, and was diagnosed with bilateral tibialis anterior muscle herniation.


Subject(s)
Aged , Female , Humans , Athletes , Fascia , Leg , Muscles , Orthopedics
11.
Korean Journal of Dermatology ; : 474-477, 2013.
Article in Korean | WPRIM | ID: wpr-186526

ABSTRACT

Lymphangioma is an uncommon, benign hamartomatous malformation that consists of dilated lymphatic channels lined by normal, single-cell lymphatic endothelia. The lymphangiomas are divided into cavernous lymphangioma, cystic hygroma, lymphangioma circumscriptum, and acquired progressive lymphangioma. Acquired lymphangioma circumscriptum usually occurs due to surgery, infection or radiotherapy, which leads to obstruction of lymphatic vessels. Clinically, the lesions appear as thick-walled, 2~5 mm translucent vesicles. Spontaneous drainage of straw-colored to milky-white fluids may occur. Herein, we report an acquired lymphangioma circumscriptum of the nipple areola without preceding causes.


Subject(s)
Drainage , Lymphangioma , Lymphangioma, Cystic , Lymphatic Vessels , Nipples
12.
Korean Journal of Dermatology ; : 734-737, 2012.
Article in Korean | WPRIM | ID: wpr-41984

ABSTRACT

Palisaded encapsulated neuroma (PEN) is a rare, benign, cutaneous nerve sheath tumor, which usually appears as a solitary asymptomatic skin-colored papule, which usually affects the face of middle-aged adults. Here, we report a case of PEN with unusual clinical features in a 23-year-old female, developed on the back, accompanied with pain sensation. Histopathologically, it appeared as a well-circumscribed, encapsulated round nodule, consisted of uniform, broad, and interlacing fascicles of the spindle cells in the dermis. On immunohistochemical staining, the tumor cells of nodule were positive for S-100 protein and neural filaments, while the capsule of the nodule was focally positive for the epithelial membrane antigen.


Subject(s)
Adult , Female , Humans , Young Adult , Dermis , Mucin-1 , Neuroma , S100 Proteins , Sensation
13.
Annals of Dermatology ; : S155-S159, 2011.
Article in English | WPRIM | ID: wpr-16447

ABSTRACT

Melanoma with rhabdoid features is an uncommon variant of malignant melanoma. Here, we describe a rare case of primary rhabdoid malignant melanoma. A 54-year-old man presented with a black tumor measuring 3x4 cm on the right forearm. Histologic sections showed a tumor mass with rhabdoid features composed entirely of polygonal neoplastic cells with eccentric nuclei, prominent nucleoli, and large hyaline cytoplasmic inclusions. The tumor cells were immunoreactive with HMB-45, S100, Fontana-Masson silver and vimentin, and negative for smooth muscle actin, CD68, CD34, CD99, synaptophysin, desmin, and PAS. The differential diagnosis for this tumor included malignant peripheral nerve sheath tumor, malignant peripheral neuroectodermal tumor and rhabdomyosarcoma. The patient was treated with a wide excision and a local skin graft. The excised tumor was entirely composed of rhabdoid tumor cells. No recurrence or metastasis was evident 4 months after removal. This article is relevant to rare cases of primary malignant melanomas showing rhabdoid tumor cells over the entire excised lesion.


Subject(s)
Humans , Middle Aged , Actins , Desmin , Diagnosis, Differential , Forearm , Hyalin , Inclusion Bodies , Melanoma , Muscle, Smooth , Neoplasm Metastasis , Neuroectodermal Tumors, Primitive, Peripheral , Peripheral Nerves , Recurrence , Rhabdoid Tumor , Rhabdomyosarcoma , Silver , Skin , Synaptophysin , Transplants , Vimentin
14.
Journal of Preventive Medicine and Public Health ; : 74-83, 2011.
Article in Korean | WPRIM | ID: wpr-104640

ABSTRACT

OBJECTIVES: This study aimed to identify and assess the factors related to the awareness, treatment, and control of hypertension based on jurisdictional areas of primary health care posts in a rural community of Korea. METHODS: This study was performed on 4598 adults aged over 30 years in a rural community and we measured their blood pressure (BP) from October. 2007 to August. 2009. Hypertension is defined as a condition characterized by a systolic BP > or =140 mmHg, a diastolic BP > or =90 mmHg or reported treatment with antihypertensive medications. We analyzed the factors related with the prevalence, awareness, treatment and control of hypertension using chi-square test and multivariate logistic regression analysis. RESULTS: The age-adjusted prevalence of hypertension was 34.7%. The age-adjusted rates of hypertension awareness, treatment and control were 50.6%, 93.9% and 64.1%, respectively. Awareness of hypertension was related with increasing age. Higher awareness was found among men who were felt more stress, were obese and had hypercholesterolemia, and among women who were regulary taking medicine for hypertension, were obese and had diabetes mellitus. In women, the hypertension treatment was related a Medical aid and education for hypertension management. Controlled hypertension was more common among men who were educated about the management of hypertension and among women who had hypercholesterolemia. CONCLUSIONS: The awareness of hypertension was low and the control of hypertension was high compared with the nationwide data (KNHANES 2005). The results suggest that understanding the characteristics of hypertension in a community is important to perform a community based hypertension control program.


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Age Factors , Ambulatory Care Facilities , Antihypertensive Agents/therapeutic use , Blood Pressure , Diabetes Complications , Hypercholesterolemia/complications , Hypertension/drug therapy , Interviews as Topic , Logistic Models , Obesity/complications , Republic of Korea , Risk Factors , Rural Population , Sex Factors , Stress, Psychological/complications
15.
Korean Journal of Dermatology ; : 393-397, 2011.
Article in Korean | WPRIM | ID: wpr-34560

ABSTRACT

BACKGROUND: Chemokines represent a superfamily of small cytokine-like chemoattractive proteins, which regulate leukocyte trafficking under homeostatic and inflammatory conditions. There have been previous reports that chemokine (C-C motif) ligand 1 (CCL1), a member of the family of chemoattractive proteins, is increasingly expressed in atopic dermatitis. OBJECTIVE: We aimed to evaluate the quantity and the pattern of CCL1 expression in atopic dermatitis (AD). METHODS: Biopsy specimens were taken from atopic skin and normal-appearing skin of AD patients as well as psoriatic skin of psoriasis patients. Quantitative real-time PCR analyses and immunohistochemistry of CCL1 expression were performed, and the quantity of CCL1 expression in acute AD was compared with those of normal-appearing atopic skin and psoriatic skin. The serum level of CCL1 was measured by ELISA. RESULTS: CCL1 was most often expressed in acute atopic skin lesions, and the absolute amount of CCL1 18s rRNA in lesional atopic skin was 14.5-fold higher than that in non-lesional atopic skin. Moreover, CCL1 was expressed within the basal layer of the epidermis as well as in the dermis of the lesional atopic skin. However, CCL1 was expressed mostly in the dermis. CONCLUSION: Therefore, CCL1 represents a chemokine that is associated with flare-up of AD, and it may play an important role as a trigger of AD in the initiation and amplification of atopic skin inflammation in the acute phase.


Subject(s)
Humans , Biopsy , Chemokines , Dermatitis, Atopic , Dermis , Epidermis , Immunohistochemistry , Inflammation , Leukocytes , Proteins , Psoriasis , Real-Time Polymerase Chain Reaction , Skin
16.
Korean Journal of Dermatology ; : 415-421, 2011.
Article in Korean | WPRIM | ID: wpr-34557

ABSTRACT

BACKGROUND: The symptoms of atopic dermatitis (AD) can limit a patient's physical and psychosocial development as well as lower their overall quality of life (QOL). These problems may have a greater effect on patients during childhood and adolescence, whose physical and psychosocial developments are vigorously ongoing. OBJECTIVE: The purpose of this study was to identify the correlation between the QOL and clinical disease severity in children and adolescents with AD. METHODS: Forty-six AD patients aged from 7 to 18 years were included in this study. A questionnaire based on Children's Dermatology Life Quality Index (CDLQI) was used to determine QOL. Eczema area and severity index (EASI) were examined to evaluate the severity of AD. RESULTS: The mean score of CDLQI was 12.83+/-6.52. Among the 10 categories, itching, treatment, and sleep showed the highest scores, whereas teasing, friendships, and school or holiday work had the lowest scores (p<0.01). The mean EASI score was 8.51+/-8.64. CDLQI and EASI scores showed significant correlation (p<0.001). Among the 10 categories of CDLQI and EASI score, the sleep, itching, and clothes categories displayed high correlation with the EASI score (p<0.001). There was no statistically significant difference between the different age groups or between boys and girls. Patients with head and neck skin lesions showed problems with personal relationships and treatment (p<0.05). CONCLUSION: AD affects the QOL of children and adolescents with AD as the severity of the disease increases. In managing AD patients, not only evaluating the clinical severity of the disease but also evaluating QOL is necessary, and emotional support could be helpful to increase the QOL of childhood and adolescent AD patients.


Subject(s)
Adolescent , Aged , Child , Humans , Dermatitis, Atopic , Dermatology , Eczema , Friends , Head , Holidays , Neck , Pruritus , Quality of Life , Surveys and Questionnaires , Skin
17.
Korean Journal of Dermatology ; : 250-254, 2011.
Article in Korean | WPRIM | ID: wpr-177819

ABSTRACT

Nodular hidradenocarcinoma was first reported as a clear-cell papillary carcinoma by Liu et al. in 1949. With a potential for uncontrollable local recurrence, it tends to metastasize and often causes death. We report a case of a 68-year-old man with nodular hidradenocarcinoma on the left preauricular area. Histopathology of the tumor showed a multilobulated intradermal mass. In the tumor nodule, there were many cystic spaces of various sizes, resulting from tumor necrosis. The tumor consisted of large, atypical, polygonal cells with eosinophilic cytoplasm, and clear cells with clear cytoplasm. Numerous mitoses were evident. We obtained positive results from an immunohistochemical study with antibodies to cytokeratins, epithelial membrane antigen, and PAS. The patient was treated with a wide local excision. However, we observed a recurrence one month later and performed a wide excision and local skin flap. There has been no evidence of recurrence or metastasis for six months after the second excision.


Subject(s)
Aged , Humans , Antibodies , Carcinoma, Papillary , Cytoplasm , Eosinophils , Keratins , Mitosis , Mucin-1 , Necrosis , Neoplasm Metastasis , Recurrence , Skin
18.
Korean Journal of Dermatology ; : 768-771, 2011.
Article in Korean | WPRIM | ID: wpr-185125

ABSTRACT

Eccrine poroma is a benign neoplasm that originates from an eccrine sweat duct. Although it is most commonly found on the soles of the feet, it has also been unusually observed on many other areas of the skin, such as the nose, neck, chest, and scalp. We report two cases of eccrine poroma occurring on the scalp, which is an unusual location.


Subject(s)
Foot , Neck , Nose , Poroma , Scalp , Skin , Sweat , Thorax
19.
Annals of Dermatology ; : S182-S184, 2011.
Article in English | WPRIM | ID: wpr-200939

ABSTRACT

Tacrolimus, a calcineurin inhibitor, formerly also known as FK506, is a macrolactam drug isolated from Streptomyces tsukubaensis. Its mode of action closely parallels the action of cyclosprorin A (CsA) and can be used for the treatment of inflammatory and autoimmune skin diseases in which systemic CsA has proved effective against psoriasis, pyoderma gangrenosum, atopic dermatitis, lupus erythematosus and graft versus host disease (GVHD). Although several cases of epidermal cysts have been reported in patients using cyclosporine and other immunosuppressants after organ transplantation; such types of cases have yet not been reported after administration of tacrolimus. However, we report herein a case of presence of multiple, various sized epidermal cysts in a renal transplant recipient receiving tacrolimus.


Subject(s)
Humans , Calcineurin , Cyclosporine , Dermatitis, Atopic , Epidermal Cyst , Graft vs Host Disease , Immunosuppressive Agents , Psoriasis , Pyoderma Gangrenosum , Skin Diseases , Streptomyces , Tacrolimus , Transplants
20.
Korean Journal of Dermatology ; : 983-992, 2011.
Article in Korean | WPRIM | ID: wpr-162688

ABSTRACT

BACKGROUND: The symptoms of atopic dermatitis (AD) may lead to the impairment of overall quality of life (QOL). Many international studies have addressed the effects of AD on the QOL of patients and their families'. However, studies from Korea are few and insufficient. OBJECTIVE: The purpose of this study was to identify the correlation between the QOL and clinical disease severity in adults with AD. METHODS: Thirty-one AD patients ranging in age from 19~43 years were included. Dermatology Life Quality Index (DLQI) and the shorter version of World Health Organization QOL assessment instrument (WHOQOL-BREF) were used to determine the QOL. Eczema area and severity index (EASI) was examined to evaluate the severity of AD. RESULTS: The mean DLQI, QOL and EASI score was 19.74+/-6.93, 3.77+/-0.76 and 9.42+/-11.12, respectively. DLQI and QOL scores significantly correlated with EASI score (p0.05). Each domain of the WHOQOL-BREF and EASI score did not show meaningful correlation (p>0.05). However, for DLQI, categories of emotion, daily life, work and school work showed a high correlation with the EASI score (all p<0.05). Both DLQI and QOL score showed significant correlation with the EASI score in females (p<0.05), but only QOL score showed high correlation in male (p<0.05). CONCLUSION: AD affects QOL of adults with AD as the disease severity increases. In managing the AD patients, evaluating the clinical severity and evaluating QOL of patients would be necessary and emotional support will be helpful.


Subject(s)
Adult , Female , Humans , Male , Dermatitis, Atopic , Dermatology , Eczema , Korea , Quality of Life , World Health Organization
SELECTION OF CITATIONS
SEARCH DETAIL