ABSTRACT
Objectives:This study aims to investigate the impact of different Low-Density Lipoprotein cholesterol(LDL-C)levels on progression of intermediate coronary stenosis,and the associated risk factors leading to the progression of such lesions. Methods:Data were collected on 219 consecutive patients admitted at the Fuwai Central China Vascular Hospital from January 2020 to February 2021,underwent angiographic examinations and diagnosed with intermediate coronary stenosis,with at least one follow-up angiography after 11 months.Offline quantitative flow ratio(QFR)analysis was performed on these cases.Patients were divided into two groups:LDL-C controlled group(LDL-C<1.8 mmol/L,148 patients with 191 vessels)and LDL-C uncontrolled group(LDL-C≥1.8 mmol/L,71 patients with 98 vessels).Coronary artery QFR and anatomical indicators such as minimal lumen diameter,minimal lumen area,percentage diameter stenosis,percentage area stenosis were compared within and between the groups.Further analysis was performed to identify influencing factors leading to changes in coronary physiological parameters derived from QFR. Results:Within the LDL-C controlled group,there was no significant difference in the QFR values of the vessels compared to baseline(P>0.05),whereas in the LDL-C uncontrolled group(P<0.05),a notable decline in QFR was observed.Patients in the LDL-C controlled group had lower rates of maximum diameter and area stenosis and higher minimum lumen diameter and area(all P<0.05).Through multifactorial Logistic regression analysis,it was found that a body mass index＞28 kg/m2,LDL-C≥1.8 mmol/L,and a history of myocardial infarction were independent risk factors leading to the decline in QFR(all P<0.05). Conclusions:It was found that patients in the LDL-C controlled group had higher coronary artery QFR,minimum lumen diameter and area,lower rates of maximum diameter and area stenosis.
ABSTRACT
[Objective] Build gangrene etiology and pathogenesis of frame structure, this paper discusses the etiology and pathogenesis theory. [Methods] Based on the time axis oriented, taking "Chinese Medical Code" as a search tool, "gangrene" as the key word, search Qin and Han Dynasties to the late Qing Dynasty physician medical books, and with the library books proofreading ,this paper will be of the ancient literature about etiology and pathogenesis of clips in series, and carries on the combation and analysis .[Result]To sum up gangrene of etiology and pathogenesis, theory framework is divided into four periods:Begin in the Qin and Han Dynasties, the development in the Wei and Jin Dynasties, rich in Song and Yuan Dynasties, perfect and enrich in the Ming-Qing Dynasty. Its etiology and pathogenesis are concise:yin-yang disharmony, cold coagulation to stasis;toxic heat accumulation. burns essence;Qi and Yin waste, blood stasis inchannels. [Conclusion] Through the gangrene of etiology and pathogenesis of frame structure building, not only can deepen the understanding of the disease, also provide a theoretical basis and ideas for the treatment of the diseases associated with modern medicine.In order to make a modest contribution to the majority of clinical work and scientific researchers.
ABSTRACT
[Objective] Build gangrene etiology and pathogenesis of frame structure, this paper discusses the etiology and pathogenesis theory. [Methods] Based on the time axis oriented, taking "Chinese Medical Code" as a search tool, "gangrene" as the key word, search Qin and Han Dynasties to the late Qing Dynasty physician medical books, and with the library books proofreading ,this paper will be of the ancient literature about etiology and pathogenesis of clips in series, and carries on the combation and analysis .[Result]To sum up gangrene of etiology and pathogenesis, theory framework is divided into four periods:Begin in the Qin and Han Dynasties, the development in the Wei and Jin Dynasties, rich in Song and Yuan Dynasties, perfect and enrich in the Ming-Qing Dynasty. Its etiology and pathogenesis are concise:yin-yang disharmony, cold coagulation to stasis;toxic heat accumulation. burns essence;Qi and Yin waste, blood stasis inchannels. [Conclusion] Through the gangrene of etiology and pathogenesis of frame structure building, not only can deepen the understanding of the disease, also provide a theoretical basis and ideas for the treatment of the diseases associated with modern medicine.In order to make a modest contribution to the majority of clinical work and scientific researchers.