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1.
Neuroscience Bulletin ; (6): 438-448, 2018.
Article in English | WPRIM | ID: wpr-777052

ABSTRACT

Diffusion-weighted magnetic resonance imaging (dMRI) is widely used to study white and gray matter (GM) micro-organization and structural connectivity in the brain. Super-resolution track-density imaging (TDI) is an image reconstruction method for dMRI data, which is capable of providing spatial resolution beyond the acquired data, as well as novel and meaningful anatomical contrast that cannot be obtained with conventional reconstruction methods. TDI has been used to reveal anatomical features in human and animal brains. In this study, we used short track TDI (stTDI), a variation of TDI with enhanced contrast for GM structures, to reconstruct direction-encoded color maps of fixed tree shrew brain. The results were compared with those obtained with the traditional diffusion tensor imaging (DTI) method. We demonstrated that fine microstructures in the tree shrew brain, such as Baillarger bands in the primary visual cortex and the longitudinal component of the mossy fibers within the hippocampal CA3 subfield, were observable with stTDI, but not with DTI reconstructions from the same dMRI data. The possible mechanisms underlying the enhanced GM contrast are discussed.


Subject(s)
Animals , Male , Brain Mapping , Diffusion Tensor Imaging , Methods , Hippocampus , Diagnostic Imaging , Image Processing, Computer-Assisted , Methods , Neural Pathways , Diagnostic Imaging , Tupaiidae , Visual Cortex , Diagnostic Imaging
2.
Journal of Forensic Medicine ; (6): 256-268, 2012.
Article in Chinese | WPRIM | ID: wpr-983744

ABSTRACT

OBJECTIVE@#To explore the applicability of magnetic resonance diffusion tensor imaging (DTI) for diagnosis of pyramidal tract damage in rats.@*METHODS@#Marmarou's model was set up, followed by DTI scanning at 3, 12, 24 and 72 h post trauma to acquire the dispersion parameter of bilateral pyramidal tracts. Moreover, axonal varicosities per square millimeter and the percentage of positive area of axons demonstrated by beta-amyloid precursor protein (beta-APP) immunostaining were obtained, as well as the mean density and sum density of neurofilament (NF) 68 immunostaining.@*RESULTS@#Axial diffusivity (AD), fraction anisotropy (FA) and relative anisotropy (RA) in the pyramidal tract were significantly and continuously reduced and reached to the bottom at 72h post trauma (P < 0.05) in accord with the gradient of axonal damage verified by beta-APP and NF68 immunostaining. Furthermore, the changes of AD, FA and RA showed a significant negative correlation with the beta-APP immunohistochemical results.@*CONCLUSION@#DTI has important value for early diagnosis in pyramidal tract damage.


Subject(s)
Animals , Male , Rats , Amyloid beta-Protein Precursor/metabolism , Anisotropy , Axons/pathology , Brain/pathology , Brain Injuries/pathology , Diffusion Magnetic Resonance Imaging/methods , Disease Models, Animal , Image Processing, Computer-Assisted , Neurofilament Proteins/metabolism , Pyramidal Tracts/pathology , Rats, Sprague-Dawley , Severity of Illness Index , Time Factors
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