ABSTRACT
Background: Cases of chronic obstructive pulmonary disease (COPD) increasing day by day. Smoking is the major causative agent for COPD. The present study undertaken to estimate the deterioration of liver functions in COPD patients due to smoking. Aims and Objectives: This study aims to investigate various liver function tests (LFTs) such as total bilirubin, alanine amino transferase/serum glutamic pyruvic transaminase (SGPT), aspartate amino transferase/SGPT, alkaline phosphatase (ALP), serum ammonia, and serum albumin among COPD patients. To correlate LFTs with forced expiratory volume at end of 1 second (FEV1) and FEV1/Forced vital capacity (FVC) ratio. Materials and Methods: In our present study, we selected 86 cases of COPD in the age group of 41–60 years. All subjects were smokers and having FEV1 <80% and FEV1/FVC <70%. A control group consists of 55 healthy individuals. LFTs were studied. FEV1 and FEV1/FVC ratio were correlated with LFTs. Statistical analysis done using SPSS software 20.0 Windows version. Results: Mean level of SGPT among cases was 117 ± 10.23 IU/L against controls who had mean SGPT 11.16 ± 8.32 which was statistically significant (P < 0.05). Likewise, mean level of s. ammonia among cases was 154 ± 10.22 mcg/dl as compare to controls who had mean 24.43 ± 7.97 mcg/dl (P < 0.05). However, no significant difference was found in rest of the LFTs. Furthermore, there was no correlation between altered LFTs and severity of COPD. Conclusion: LFTs are significantly altered in COPD patients due to smoking. Corticosteroids treatment must not be initiated without investigating LFTs among COPD patients.