Primary persistent glomerulonephritis in Filipino children (a prospecitve study of 17 cases over a period of seven years)

Seventeen children, with current age; of 7-5/12 to 15-10/12 years, have been diagnosed to have primary persistent glomerulonephritis of 6 months to 7-3/12 years duration. There were 11 females and 6 males majority of which were in the age bracket of 5 to 8 years at onset of the diseaseThree distinct initial clinical patterns of presentation were noted: (1) a picture of nephrotic syndrome, (2) a picture resembling acute glomerulonephritis, and (3) a picture of gross hematuria aloneIn patients with far advanced disease, hypertension, anemia, and sustained azotemia were present. None of non-uremics showed this triad of symptomsIn the 10 non-uremic survivors, a considerable amount of clinical improvement ensued but the urinary abnormalities, in particular that of persistent or recurrent proteinuria with or without microhematuria, failed to clear with timeThe striking features of this study are: (1) the lack of parallelism between the initial presenting clinical patterns and the morphologic lesions on renal biopsy, and (2) the lack of correlation between the follow-up histologic changes on subsequent biopsies and ensuing clinical courseFrom the results of the present study, we would like to make the following conclusions: 1. Primary persistent glomerulonephritis of whatever pathologic type may become clinically manifest in a variety of ways2. It may be clinically indistinguisable from acute glomerulophritis and certain cases of lipoid nephrosis3. The clinical manifestations are as variable as the different pathologic changes. The clinical spectrum may range from a patient with hematuria only to a patient in a state of chronic renal insufficiency4. The long-term clinical course which is the major determinant in diagnosis may be as variable as the initial clinical pattern. The spectrum may vary from a patient with proteinuria only to a patient who is dying of uremia5. The course of the disease is measured in several months or years and not in a few weeks. The prolonged clinical course renders prognosis a complete uncertainty. The ultimate outcome of the disease cannot be anticipated. (Summary and Conclusions)

Anaphylactoid purpura associated with cutaneous necrosis and gangrene and its treatment with dextran infusions

A case of a 4-year old Filipino female with anaphylactoid purpura complicated by cutaneous necrosis and gangrene was herein reported. Therapy with 6% Dextran infusions was dramatic and rewarding as evidenced by cessation of further progression of the ischemic lesions and the eventual drying up of almost all cutaneous manifestations. Mention was made of the extreme rarity of the present case as attested by only a few cases so far reported in the literature. (Summary)

Battered child syndrome in a Filipino infant a case with multiple skeletal injuries

A case of battered child syndrome in an 11-month old male infant is herein reported and described. He presented with multiple skeletal deformities, severe anemia, malnutrition, and numerous scars. The case was referred to the Protective Services of the Bureau of Child and Youth Welfare of the Department of Social Welfare for final disposition. The roles of the physician, the law, and the community were described briefly. It is the impression of our group that the battered child syndrome is by no means a rarity in our country.(Summary)

Effects of intraperitoneal injections of "Tungog" in white sprague rats-inquiry on "Tungog" (an additive of tuba)

A 30-minutes infusion of "tungog" in normal saline was injected intraperitoneally to 59 white Sprague rats. Marked clinical and anatomic changes developed in animals which received 10 to 20 serial injections of 0.5 cc of the infusion 1 to 2 times a week plus a single additional dose of 0.75 cc per 100-gram body weight. The liver and spleen were contracted and deformed in more than 50% of the subjects. The hepatic cells showed varying degrees of hyaline and feathery degeneration which sometimes proceeded to necrosis. Concomitantly, there was secondary regenerating hyperplasia often to a marked degree. The changes in the spleen were described. (Author)

Open heart operations using disposable plastic oxygenators, 5% dextrose in distilled water prime, normothermia, and a sigmamotor pump (T-M2)

Open heart operations were successfully performed on six consecutive patients at the Philippine General Hospital. Total cardiopulmonary bypass was accomplished using disposable plastic oxygenators, five percent dextrose in distilled water prime, normothermia and a single sigmamotor pump (T-M2). The technic of perusion, clinical material, physiologic data gathered and the financial costs of these operations were discussed. All the patients survived their operations. No complication could be attributable to the method of cardiopulmonary bypass employed. The technic of cardiopulmonary bypass described appears practical, safe, and relatively inexpensive. This method of bypass has been adopted for use by the Department of Surgery for all types of open heart operations. (Author)

Studies on host resistance to cancer VI. Electrophoretic studies in health and neoplastic disease: a preliminary report

Electrophoretic studies were made on tissue extract and sera from normal strong A mice, non-pre-treated mice challenged with Ehrlich Ascites Tumor cells; mice pre-treated with formalin-killed ascites Tumor cells prior to challenge with live EAT cells; normal human beings; patients with non-neoplastic diseases; and patients with cancer. The significance of the findings were analyzed. A consideration that the changes in the pre-treated and challenged mice indicated that the development of immunity was made. (Summary)

Acute renal failure in a neonate with sepsis managed by peritoneal dialysis

This report describes an anuric neonate with sepsis managed by peritoneal dialysis. It was possible to continue with massive antibiotic therapy on account of this procedure. The safety and efficacy of peritoneal dialysis in the neonatal period cannot be over-emphasized. Its potentiality as a life-saving device should be a major concern. The small size of the patient should cause no hindrance in the performance of this procedure, much less any decision to employ it should not be deferred so long as there is a sound rationale for its use. (Summary and conclusions)