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OBJECTIVE: To analyze the current status of silica dust hazard in workplaces of Jiangxi Province. METHODS: The level of silica dust in the air of workplaces, occupational health examination of the dust-exposed workers and diagnosis of occupational disease in 1 557 enterprises in Jiangxi Province were investigated and analyzed. RESULTS: The 1 557 enterprises were included in eight industries, and the main types of enterprises were non-coal mining, ceramic products manufacturing and stone processing industry(a total of 85.16%). There were 4 029 jobs/positions that were involved in exposure to silica dust in these workplaces. Among them, the exposure concentration of time weighted average(C_(TWA)) of total dust and respirable dust exceeded 21.52% and 20.55%, respectively. The posts where the total dust and respirable dust that exceed the standard were found in the quartz sand processing industry, non-ferrous metal smelting industry and stone processing industry, that were the top three among the eight industries(all P<0.01). Among the 828 posts with C_(TWA) of respiratory dust exceeding the standard, the C_(TWA) exceeding rate of mild-, moderate-and high-hazardous jobs were 3.87%(156/4 029), 1.66%(67/4 029) and 15.02%(605/4 029), respectively. Among 23 643 dust-exposed workers, the detection rates of occupational contraindications and suspected silicosis were 2.06% and 1.51%, and the prevalence of silicosis was 1.21%. CONCLUSION: Silica dust hazard in workplaces of quartz sand processing industry, non-ferrous metal smelting industry and stone processing industry are serious in Jiangxi Province. The supervision and management of occupational health should be further strengthened to guarantee the occupational health of workers.
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This paper aims to understand the blood pressure control status for hypertension patients, and discuss the relationship between social support, medication compliance and blood pressure for hypertensive patients. The survey objective was the hypertensive patients in chronic disease management system in Xinxiang city. The survey was conducted as the questionnaire survey filled by objectives. Social support rating scale and medication therapy compliance questionnaire was utilized to evaluate the patients' social support and medication therapy compliance. 1095 patients in medication were investigated, the blood pressure of 66.6% investigated objectives was controlled at target levels [<140/90 mmHg], 70.0% investigated objectives have good medication therapy compliance; the overall social support score for hypertensive patients in medication was [40.01+/- 6.54] points, the subjective support score, objective support score and support utilization degree score were respectively [24.43+/- 4.61] points, [8.59+/- 2.59] points and [7.00+/- 2.06] points; Rank correlation coefficient of Spearman illustrated that the support utilization rating evaluation was apparently correlated to medication therapy compliance [rs=0.88, P<0.01]; multivariate analysis proved that the protective factors for medication therapy compliance were the high support utilization rate [OR 1.62; 95%CI 1.19tildE[2].05], long hypertensive duration [5tilde10 years: OR 2.01, 95%CI 1.42tildE[2].73; more than 10 years: OR 1.46, 95%CI 1.01tilde1.99] and high average monthly household income [OR 2.03, 95%CI 1.45tildE[2].69]; Risk factor for blood pressure control were male [OR 0.61, 95% CI 0.47tilde0.79] and high hypertensive grade [OR 0.31, 95%CI 0.19tilde0.44]; The protective factors for blood pressure control was good medication therapy compliance [OR 1.54, 95%CI 1.22 tilde 1.89], [average P<0.05]. It required to build effective social support system, increase patients' social support utilization degree, emphasized the intervention on low average monthly household incomes, male higher rate, higher hypertensive degree, and further improve the medication therapy compliance and hypertensive control rate of hypertensive patients
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Objective Pueraria extract puerarin,HPLC assay puerarin extract and compare different doses of correlation with the hang-over effect of puerarin evaluate different doses of puerarin liver hangover effect. Methods Extracted under optimal conditions obtained in the previous experiment puerarin spare,HPLC method for qualitative and quantitative detection of alcohol extract of kudzu root ( PRE) ,the male Kunming mice were randomly divided into control group,positive control group and puerarin group,each group of 10. Give mice fed pueraria extract,30 min after administration of liquor,drunk mice sobering observation time and the determination of mouse liver ADH,GOT,GPT con-tent in order to investigate the effect of puerarin on drunken mice. Results HPLC fraction was measured at 8 times the volume of 70% etha-nol,60 ℃ constant temperature water bath shaker at 30 min for optimal extraction conditions puerarin extraction. Compared with the positive control groups:low,medium and high doses of alcohol extract of pueraria can significantly shorten the time to sober up drunken mice,the dose of PRE could effectively inhibit the absorption of alcohol,reduce liver tissue ADH,GOT,GPT,the effects of high doses of PRE absorption of alcohol was small. Conclusion HPLC method capable of puerarin extract the qualitative and quantitative determination of puerarin on liver injury caused by acute alcoholism a protective regulatory role,and the hangover effect of puerarin dose showed a good positive correlation.
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Objective To detect the expression of urinary nuclear matrix protein 22(NMP22) and cytokeratin 20(CK20) mRNA in the monitoring of bladder tumor recurrence ,and to explore the clinical value of combined detection of urinary NMP22 and CK20 mRNA in the monitoring of bladder tumor recurrence .Methods Enzyme‐linked immunosorbent assay(ELISA) and nested reverse transcriptase polymerase chain reaction(Nested RT‐PCR) were used to detect the expression of NMP22 and CK20 mRNA in the u‐rine of 46 patients with recurrent bladder cancer tumor (recurrent group) ,66 patients without recurrent tumor (no‐recurrent group) and 40 healthy volunteers(control group) respectively .Results The expression of NMP22 and CK20 mRNA in the urine of control group were negative .There was statistically significant difference between the positive expression rate of NMP 22 and CK20 mRNA in the urines of the recurrent group[78 .3% (36/46) ,80 .4% (37/46))] and that of the no‐recurrent group[6 .1% (4/62) , 6 .1% (4/62)] and the control group respectively (P0 .05) .The expression level of NMP22 in recurrent tumor increased obviously along with the progression of the pathological grade and clinical classification of tumor (P0 .05) .Conclusion The positive expression of CK20 mRNA may also indicate tumor multiplicity .Combined detection of NM P22 and CK20 mRNA significantly increases the sensitivity and specificity in clinical detection .
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Objective To probe into the influencing factors and countermeasurses for clinical nursing teaching in pediatric department. Methods From June 2009 to June 2010, 86 nursing interns in pediatric department were selected, and a retrospective analysis was carried out. Results In the 86 interns in nursing practice, influencing factors of clinical nursing teaching included: 65 interns thought of department factors, accounting for 75.58%; 61 interns thought of nursing students factors, accounting for 70.93%; 59 interns thought of teacher factors, accounting for 68.60%; 57 interns thought of social factors, accounting for 66.28%. Conclusions Many factors influence pediatric clinical nursing teaching, we should strictly implement the rules and regulations and to actively take measures to comprehensively improve the quality of clinical practice for nursing students.
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Objective To investigate the effect of psychological nursing in children with supracondylar fracture of humerus undergoing open reduction and internal fuxation. Methods 63 children with supracondylar fracture of humerus undergoing open reduction and internal fixation were randomly divided into the control group (30 cases) and the observation group (33 cases), the control group were given routine nursing care, the observation group received psychological intervention in addition to the routine nursing care, the nursing effect of two groups were compared. Results In the observation group, the excellent and good rate was 97.0%, significantly higher than 80.0% of the control group, the incidence of complications of the observation group was 6.1%, slightly lower than 10.0% of the control group, there was no significant difference between two groups; the children (or) family members,satisfaction degree nursing staff in the observation group was 97.0%, significantly higher than 76.7% of the control group, the difference between the two groups was statistically significant. Conclusions Psychological nursing based upon routine nursing in children with supracondylar fracture of humerus undergoing open reduction and internal fixation proved satisfactory clinical results, and conducive to the rehabilitation of patients, so it is worth popularizing.
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Objective To explore the effects of dexamethasone on ovulation induction in polycystic ovary syndrome (PCOS).Methods This clinical study included 68 women with PCOS, which of them were divided into two groups: 34 in dexamethasone treating(dexamethasone combined with ovulation induction) and 34 in con-trol(ovulation induction treatment only).Subsequently, comparisons were made between pre and after drug treat-ment in two groups, the main indexes were the levels of testosterone(T), luteinizing hormone(LH), follicle stim-ulating hormone(FSH), growth rate of follicle, and body mass index(BMI).And we have also considered the o-vulation rate and pregnancy rate, and compared these indexes in dexamethasone treating group with control group.Results There were significant differences between pre and after dexamethasone treatment in the levels of T in treatment group(P 0.05).LH had decreased significantly after treatment in both two groups (P 0.05).The growthrate of follicle of two groups had elevated after treatment (P 0.05).There were not significant differences between pre and after treatment in the levels of BMI in both two groups (P > 0.05).Conclusions Dexamethasone can decrease the T in plasm levels.It is good for ovulation induction in PCOS.
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ObjectiveTo observe testis tissue changes of experimental cryptorchidism after orchiopexy in various-day-rats.MethodsSeventy-two Sprague-Dawley(SD) male rats were divided into 3 groups randomly and made artificial cryptorchidism:unilateral cryptorchidism group(n=24),bilateral cryptorchidism group(n=24)and sham operation group(n=24)at age 21-day-old.Intra-abdominal testicle was resetting in 2 weeks,at age 40 days and 60 days,the rats were sacrificed for detection tubular fertility index(TFI) and mean tubular diametar(MTD) with hematoxylin-eosine staining and germ cell apoptosis by terminal deoxynucleotidyl transferase mediated d-UTP nick end labeling(TUNEL) assay.ResultsThere were significant differences of MTD,TFI and apoptosis index(AI) between cryptorchidism and scrotal testes(P0.05).The AI of cryptorchidism testes of unilateral cryptorchidism group were significantly lower than that of bilateral cryptorchidism group in 40 days(P0.05).ConclusionsAI of artificial resetting testis is increased and contralateral descended testes in unila-teral cryptorchidism have various damage.It is to lighten that pathological damage of testes of cryptorchidism with prolongation of reset time.
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Objective:To determine the expression of estrogen receptor ? and estrogen receptor ? (ER?、ER?) in the endometrium of rats with polycystic ovary syndrome(PCOS). Methods: PCOS model was made by dehydroepiandrosterone(DHEA)and insuline(n=30). The serum hormone levels were examined by radioimmunoassay. The expression of the mRNA and protein of ER? and ER? in endometrium of twogroups were observed by using reverse transcription polymerase chain reaction(RT-PCR)and immunohistochemistry. Results: The expression of protein of ER? in PCOS group in endometrium was significantly higher than those in the control group(P0.05). RT-PCR analysis showed the same expression of ER? mRNA and ER? mRNA in endometrium as immunohistochemistry. Conclusion: ER? in endometrium of PCOS rats is expressed excessively.