reaction of cyanoacetyl hydrazide with cyclopentanone: synthesis of coumarin, pyridine and thiazole derivatives

This work concerns with studying the reaction of cyanoacetyl hydrazide with cyclopentanone to give the hydrazide-hydrazone derivative 3. The reactivity of compound 3 towards different chemical reagents was studied to give coumarin, pyridine and thiazole derivatives. The antimicrobial evaluation of the synthesized products was studied where most of them showed interesting activities