Chinese Medicine Regulates DNA Methylation to Treat Haematological Malignancies: A New Paradigm of "State-Target Medicine" / 中国结合医学杂志

Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies (HMs). Targeted therapy, aiming for DNA methylation, is an effective mainstay of modern medicine; however, many issues remain to be addressed. The progress of epigenetic studies and the proposed theory of "state-target medicine" have provided conditions to form a new treatment paradigm that combines the "body state adjustment" of CM with targeted therapy. We discussed the correlation between Chinese medicine (CM) syndromes/states and DNA methylation in this paper. Additionally, the latest research findings on the intervention and regulation of DNA methylation in HMs, including the core targets, therapy status, CM compounds and active components of the Chinese materia medica were concisely summarized to establish a theoretical foundation of "state-target synchronous conditioning" pattern of integrative medicine for HMs, simultaneously leading a new perspective in clinical diagnosis and therapy.

Research progress on regulation and construction of bone marrow hematopoietic niche by traditional Chinese medicine / 中草药

The bone marrow hematopoietic niche is the place where hematopoietic stem cells and progenitors survive. It is not only related to the hematopoiesis function, but also its steady-state disorders and abnormalities can induce a variety of hematologic diseases, which will even be adapted by malignant cells such as leukemia stem cells, so as to cause seriously poor prognosis. Therefore, it is of great significance to the regulation and construction of the bone marrow niche. In this review, we outline the composition, physiological and pathological basis of bone marrow hematopoietic niche, from the regulation of Chinese materia medica components and TCM formula to graphically analyze the target and effect of drug efficacy. Then, combined with the clinical practice for integrating and summarizing decentralized research, aiming to provide new directions and perspectives for the TCM research and treatment of hematologic diseases.