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An. bras. dermatol ; 88(6,supl.1): 109-112, Nov-Dec/2013. graf
Article in English | LILACS | ID: lil-696808

ABSTRACT

Hepatitis C is an inflammatory disease of the liver caused by a single-stranded RNA virus belonging to the Hepacivirus genus in the Flaviviridae family, called the hepatitis C virus. After initial infection, 70% to 85% of the patients develop chronic hepatitis C with hepatic fibrosis. In addition to specific liver changes, various extrahepatic manifestations have been associated with the hepatitis C virus infection or with medications used to treat the condition. We report the case of a patient with chronic hepatitis C who presented with the signs and symptoms of borderline tuberculoid leprosy and type 1 reaction four months after the start of treatment with a pegylated interferon/ribavirin combination.


A hepatite C é uma doença inflamatória fígado causada por um vírus RNA de fita simples, pertencente ao gênero Hepacivirus e à família Flaviviridae, denominado de vírus da hepatite C. Após infecção inicial 70 a 85% dos pacientes infectados evoluem para hepatite C crônica, com fibrose progressiva. Além das alterações hepáticas específicas, várias manifestações extra-hepáticas têm sido relacionadas à infecção pelo vírus da hepatite C ou às medicações utilizadas no seu tratamento. Nesse trabalho, apresenta-se caso de paciente portador de hepatite C crônica, que manifestou um quadro hanseníase boderline tuberculóide e reação hansênica do tipo I, quatro meses após início do tratamento com interferon peguilado associado à ribavirina.


Subject(s)
Humans , Male , Middle Aged , Antiviral Agents/adverse effects , Hepatitis C/drug therapy , Interferons/adverse effects , Leprosy, Borderline/chemically induced , Leprosy, Tuberculoid/chemically induced , Ribavirin/adverse effects , Acute-Phase Reaction/chemically induced , Drug Therapy, Combination/adverse effects , Hepatitis C/complications , Leprosy, Borderline/pathology , Leprosy, Tuberculoid/pathology
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