The significance of serum anti-titin antibodies and anti-acetylcholine receptor antibodies in patients with myasthenia gravis / 中华神经医学杂志

Objective To study the clinical significance of serum anti-Titin antibodies and thecorrelation between anti-Titin anbibodies and anti-acetyleholine receptor (AchR) antibodies in patientswith myasthenia gravis (MG). Methods We detected anti-Titin antibodies and anti-AchR antibodieswith enzyme linked immunosorbent assay (ELISA) in the sera from 81 cases of MG groups includingearly-onset MG, late-onset MG and MG with thymoma (MGT). The positive rates were compared amongthese groups. Results The positive rates of anti-Titin antibodies in sera of MG patients weresignificantly higher than controls (P<0.01). The mean titers and the positive rates of anti-Titin antibodieswere significantly higher in MGT (80%) and late-onset MG (69.4%) subgroups than in the early-onsetMG subgroup (25%). In contrast, the positive rates and mean titers of AchR antibodies in the early-onsetMG subgroup were higher than those in the late-onset MG subgroup. The detections of serum anti-Titinantibodies and AchR antibodies were consistent with the diagnosis of MG. Conclusion Anti-Titinantibodies are specific for MG. They often present in the sera of patients with MGT and late-onset MG.The positive rates and mean titers of AchR antibodies in early-onset MG patients sera are higher thanthose in late-onset MG patients. These features prompt fiu'ther studies on the pathogenesis of MG. Testingfor a combination of anti-Titin antibodies and AchR antibodies gives the higher sensitivity for thedetection of MG than each antibody alone.

Study of GRE-T_2 ~* WI MRI diagnosing microbleeding in stroke patients / 中华神经科杂志

Objective To investigate the microbleeding incidence of healthy eldery population and patients with stroke.Methods 30 cases of healthy eldery population,32 cases of cerebral hemorrhage,46 cases of patients with ischemic cerebral vascular diseases were performed of MRI and GRE-T_2 ~* WI examination.Results The microbleeding incidences was 37.5% in cerebral hemorrhage group,28.1% in multiple cerebral infarction group,25.0% in Binswanger's disease group.The most frequently seen microbleeding foci located in ganglia areas,then in thalamus areas,subcortical areas and brain stem,last in cerebellar.Conclusion GRE-T_2 ~* WI,helpful for finding microbleeding and indicating lesion degree of microblooding vessels,plays an important role in the diagnosis of stroke and decision making of treatment.