ABSTRACT
Background: Central precocious puberty [CPP] is characterized by premature activation of the Hypothalamic-pituitary-gonadal axis, resulting In accelerated growth and bone maturation with clinical signs of puberty before the age of 8 years in girls. The most common type of CPP in girls is the constitutional type. Short adult stature is one of the most important outcomes of CPP that is due to early closure of epiphyses. The aim of this study was to determine the effect of a LHRH agonist on the final height of girls with precocious puberty
Materials and Methods: In this prospective study, 15 girls with a definite diagnosis of precocious puberty were selected and treated with decapeptyl, a longacting LHRH agonist, 60microg per kilogram of body weight as i.m. injections every 28 days
Results: The age and bone age ranges of the patients were 8-9.5 and 8-11.5 years, respectively. The predicted adult height increased from 151.34±3.6 cm at the beginning of treatment to 158.7±4.08 cm on the iast examination after 5 years of treatment [p<0.001]
Conclusion: The present data indicates that treatment with long-acting LHRH-agonists markedly affects final height in epp without any significant complications