ABSTRACT
A new hypothesis has been proposed to explain excessive callus formation seen after injury to brain or spinal cord. Nervous tissue is very active metabolically and when damaged or inflammed it extracts, utilises and inactivates most of the corticosteroids and other anti-inflammatory substances present in the blood. Therefore now very little active corticosteroids are left to exhibit the inhibitory effect on callus formation. This leads to faster fracture healing with excessive callus formation in head or spinal cord injured patients.
Subject(s)
Adolescent , Adult , Aged , Bony Callus/physiology , Brain Injuries/complications , Child , Female , Femoral Fractures/complications , Fracture Healing/physiology , Humans , Male , Middle AgedSubject(s)
Adult , Calcinosis/complications , Carpal Tunnel Syndrome/etiology , Female , Humans , WristABSTRACT
The effect of 4 weeks, 8 weeks and more than one year of treatment with the non-selective beta-receptor blocking agent, propranolol was investigated on glucose tolerance by oral glucose tolerance test. Statistically significant decrease in blood glucose level was observed in oral glucose tolerance test after 4 weeks and 8 weeks therapy with propranolol (P = less than .01 and less than .001). Statistically significant increase in glucose tolerance was also observed in all the samples of blood glucose level (P = less than .001) after more than one year therapy.