ABSTRACT
Objective: To investigate the clinicopathological features, diagnosis and differential diagnosis of ectopic meningothelial hamartoma (EMH). Methods: Three cases of EMH diagnosed in the First Affiliated Hospital of Nanjing Medical University from January 2014 to December 2020 were enrolled. All cases were evaluated by clinical and imaging features, HE and immunohistochemical staining, and the relevant literature was reviewed. Results: There were one male and two female patients, aged 2, 67 and 19 years, respectively. Clinically, they presented as skin masses in the head and face region (two cases) and sacro-coccygeal region (one case). Grossly, the lesions ranged in size from 1.6 cm to 8.9 cm. Microscopically, the lesions were ill-defined, and located in the dermis and subcutis, and showed pseudovascular channels lined by monolayer of cuboidal to flattened epithelium with mild atypia, with variable cystic cavity formation. There was prominent interstitial fibrosis. Concentric, lamellated, onion skin-like arrangement with short spindle or ovoid cells and psammoma bodies were noted. Immunohistochemically, these cells were strongly positive for SSTR2, EMA, vimentin and progesterone receptor. Ki-67 positive index was low, approximately 1%. Conclusions: EMH is uncommon. Definitive diagnosis relies on histopathologic examination. The importance in recognizing the lesions is to differentiate from other more aggressive tumors.
Subject(s)
Female , Humans , Male , Choristoma/pathology , Diagnosis, Differential , Hamartoma/pathology , Meninges , Skin Diseases/pathologyABSTRACT
Purpose To evaluate the effects of double stai-ning of elastic fibers and broad-spectrum keratin and simple e-lastic fiber staining in pleural invasion of lung cancer. Methods The pathological data of lung cancer from June 2015 to July 2016 in Jiangsu Province Hospital were retrospectively analyzed, of which 104 cases presented with suspected pleural invasion by HE staining. Double staining of elastic fibers and broad-spec- trum keratin and simple elastic fiber staining were adopted to compare their effects for pathological analysis on pleural invasion of lung cancer. Results 46 patients with positive pleural inva-sion were reported by simple elastic fiber staining, whereas 63 patients with positive pleural invasion were detected by double staining. The positive rate of double staining was 60. 58% , however the positive rate of simple elastic fiber staining was 44. 23% . The ability of double staining on detection of pleural invasion was significantly higher than simple elastic fiber stai-ning. Furthermore, following pathological analysis revealed that patients with contradictory results using double staining and sim-ple staining were mostly diagnosed by presence of single or sever-al broad-spectrum keratin-positive tumor cells which invaded the pleura. Conclusion Compared with simple elastic fiber stai-ning, double staining of elastic fibers and broad-spectrum keratin combines the advantages of these two methods, which can simul- taneously visualize the pleural and tumor cells, so as to better observe the adjacent relationship between tumor cells and sur-rounding pleura. Double staining of elastic fibers and broad-spectrum keratin is an efficient method for pathological diagnosis and benefit to following clinical treatment of patients with positive pleural invasion of lung cancer.
ABSTRACT
<p><b>OBJECTIVE</b>To clarify the clinical and morphological features of adult prostate sarcoma (APS) and to further improve the knowledge and diagnostic accuracy for APS.</p><p><b>METHODS</b>Fifteen cases of APS were observed and analyzed on the clinical symptom, pathological features, treatment and prognosis.</p><p><b>RESULTS</b>Age of onset ranged from 22 to 77 years (mean 46.3 years). The majority of cases were presented with dysuresia. By digital rectal examination and imaging of the prostate, APS was often identified as a large tumor mass. There were 6 cases of leiomyosarcomas, 6 embryonal rhabdomyosarcomas, and 3 fibrosarcomas in this series. Follow-up data were available for 12 cases: 7 cases died of the disease between 9 days and 360 days after surgery. Among 5 survived patients, 3 cases had recurrence after 2 to 24 months follow-up.</p><p><b>CONCLUSIONS</b>APS is a rare tumor that typically has clinical features: earlier age of onset, fast-appeared urinary tract symptoms, significant mass effects, and poor outcome. Level of prostate specific antigen (PSA) is usually normal or lower. Final diagnosis relies on the features of histology and immunohistochemistry expression profile.</p>