ABSTRACT
Tumors of the central nervous system constitute the largest group of solid neoplasms in children and are second only to leukemia in their overall frequency during childhood. The main purpose of the present study is to determine the incidence, age, sex, location and histological diagnosis of CNS tumors in children, less than 15 years of age, in the Mofid Children's Hospital, in the past 10 years. In this descriptive retrospective study we reviewed the medical records of 143 children with diagnosis of CNS tumors admitted during the past 10 years in neurology and surgery departments of Mofid Children's Hospital between the years 1996 and 2006. During the 10 year study period, CNS tumor was diagnosed in 143 patients; of these tumors, 119 were intracranial and 58 were intraspinal; 51.3% of brain tumors were located in the supratentorial and 48.7% in the infratentorial regions. The most common intracranial neoplasms were astrocytic tumors [36.8%], embryonal tumors [31.1%] and ependymal tumors [13.4%]. Of the intraspinal neoplasms the most frequently noted were embryonal tumors [37.5%], mesenchymal meningothelial tumors [20.8%], followed by astrocytic tumors [16.7%]. The median age at diagnosis was 8.9 +/- 4.1 years with a male to female ratio of 1.4:1 [P<0.5]. The most common intracranial astrocytic and embryonal neoplasms were pilocytic astrocytoma and medulloblastoma/ PNET respectively. Brain tumors in children constitute a diverse group in terms of incidence, distribution and histopathological diagnosis