Observation on the curative effect of modified amniotic membrane transplantation for agricultural pterygium / 中国医学装备

Objective:To observe the curative effect of modified amniotic membrane transplantation for agricultural pterygium.Methods: A total of 276 cases (276 eyes) with early pterygium were randomized divided into traditional group (138 cases) and modified group (138 cases) as random table. The traditional group was treated with pterygium excision in combination with autologous conjunctival transplantation; the modified group was treated with modified amniotic membrane transplantation; to observe the curative effect of the two groups.Results: After all of patients were followed up for 1 year, 122 cases were cured and 16 cases were recurrence, and the recovery rate was 88.41% in traditional group; 131 cases were cured and only 7 cases were recurrence, and the recovery rate was 94.93% in modified group and was better than traditional group; the difference between the two groups was statistical significant (x2=5.02,P<0.05).Conclusion: The modified amniotic membrane transplantation method is simple in operation, mini invasive for eye tissue, and can retain conjunctival tissue in utmost; it also can improve success rate of surgery and be an effective mean for treatment of pterygium.

Inhibitory effects of curcumin on inflammatory cytokines in rats with paraquat poisoning / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To explore the mechanism of paraquat (PQ) poisoning and to observe the changes in inflammatory cytokines in PQ-exposed rats treated in different ways.</p><p><b>METHODS</b>Fifty 8-week-old clean male Wistar rats were randomly divided into high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin group, PQ poisoning group, and blank control group. On days 1, 3, 5, 7, 14, and 21 after PQ exposure, serum levels of transforming growth factor-β₁(TGF-β₁) , tumor necrosis factor-α (TNF-α) , and interleukin-6 (IL-6) were measured. The pathological changes in lung tissue were evaluated by HE staining.</p><p><b>RESULTS</b>Compared with the blank control group, the high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin group, and PQ poisoning group had significantly increased serum levels of TGF-β₁, TNF-α, and IL-6 (P<0.05) , and the three cytokines in each group reached peak levels on day 14 after exposure. Compared with the PQ poisoning group, the high-dose curcumin group had significantly reduced serum levels of TGF-β₁, TNF-α, and IL-6 (P<0.05). On day 21 after exposure, there were no significant differences in serum levels of TGF-β₁, TNF-α, and IL-6 between the high-dose curcumin plus conventional treatment group and the low-dose curcumin plus conventional treatment group (P>0.05). The HE staining revealed alveolar inflammatory changes on days 1~7 and massive pulmonary fibrosis on days 14~21 in the high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin group, and PQ poisoning group, but the above changes were milder in the high-dose curcumin group than in the PQ poisoning group.</p><p><b>CONCLUSION</b>For rats with PQ poisoning, curcumin can significantly reduce inflammatory response and pathological changes in lung tissue and inhibit and delay the development and progression of body injury.</p>

Clinical effect of 58 patients with severe craniocerebral injury treated by surgery / 中国基层医药

Objective To investigate the clinical effect of standard large bone flap decompression for severe craniocerebral injury.Methods This study was performed in 58 patients with severe traumatic brain injury,according to different surgical methods,the patients were divided into control group and study group,29 cases in each group.The control group was treated with conventional bone flap craniotomy,and the study group was treated with large bone flap decompression surgery.The clinical effect and complications were compared between the two groups.Results After operation,the patients were followed up for 5 months.The mortality of the study group (10.34%)was significantly lower than that of the control group (27.59%),and the difference was statistically significant (χ2 =3.98,P <0.05).In addition,the good rate of the study group (55.17%)was significantly higher than that of the control group (27.59%),and the difference was significant (χ2 =4.55,P <0.05).The preoperative intracranial pressure had no significant difference between the two groups.While at postoperative 1d,3d and 5d,the intracranial pressure of the study group was significantly lower than that of the control group,and the difference was statistically significant (t =3.55,4.02,6.12,all P <0.05).The scores of GOS and BAI in the study group were significantly higher than those in the control group (t =5.02,4.21,P <0.05 ).The incidence rates of complications such as cerebrospinal fluid leakage,trauma of cerebral infarction,trauma of epilepsy,hydrocephalus,wound infection of the study group were sig-nificantly lower than those of the control group,and the differences were statistically significant (χ2 =4.00,5.02, 456,4.22,3.99,all P <0.05).Conclusion Compared with conventional craniotomy,open standard big bone flap decompression can significantly reduce the mortality rate,decrease intracranial pressure,and improve the quality of life of patients,it has better curative effect and prognosis for patients with severe craniocerebral injury,and is worthy of clinical application.

The valuation of dual source CT for diagnosis of urinary stone composi-tion / 中国现代医生

Objective To investigate the diagnostic value of dual source CT on urinary stone constituents qualitative,aims to improve the correct diagnosis rate and the clinical curative effect. Methods Selected 53 patients with suspected urinary calculi hospitalized because of abdominal pain in our hospital from August 2014 to December 2014, 53 patients with suspected urinary calculi treated with dual source CT scan, stone composition, compared with stone infrared spectrum analysis results after the operation were analyzed. Results Dual source CT showed a total of 42 cases patients with gallstone,89 stones,postoperative infrared spectroscopy confirmed that a total of 35 cases of gallstone patients,a total of 66 star stone. There were stone of 8 components, mainly oxalic acid calculi, 30 patients, 59(89.4%) stones;followed by uric acid calculi in 3 cases,4(6.2%),2 cases of other stones 3(4.4%). Dual source CT showed containing calcium oxalate stone 76,accounting for all the stones of the 85.4%(76/89),spectrum proved that the 59(77.6%). Du-al energy that contain calcium oxalate (59/62) with accuracy of 95.2%, sensitivity 100%, specificity 61.0%(36/59),and negative predictive value of 100%. Pure calcium oxalate(20/59)with accuracy of 38.9%,sensitivity of 100%,and negative predictive value of 100%. Conclusion Using dual source CT in diagnosis of urinary calculi in the analysis of the composition of the stones in the body, good accuracy, and can better distinguish the different components of the stone,make the qualitative judgment, in order to provide evidence for clinical treatment. In the group of patients with oxalate stones up to about 90%,different from previous research,analysis may be related to regional,national,differ-ences in diet,pending further study.