ABSTRACT
Objective@#To investigate whether the combination of oral propranolol and topical 0.5% timolol maleate cream is more effective than oral propranolol alone for treating infantile hemangioma (IH).@*Methods@#From September 2015 to July 2016, 14 patients with proliferative IH, visited the infantile hemangioma outpatient clinic of the Department of Plastic and Reconstructive Surgery of Shanghai 9th People′s Hospital, were enrolled in this study. All patients took oral propranolol. Half of each IH lesion was treated with 0.5% timolol maleate cream. There were 5 male patients and 9 female patients, aged from 1.5 to 5.0 months. After 4 months of treatment, the color, size, extent, volume and the overall clinical outcomes of each lesion were measured, and the side effects were recorded. The therapeutic outcomes of oral propranolol alone and the combination of propranolol and timolol were analyzed and compared using Wilcoxon matched-pair signed-rank nonparametric tests.@*Results@#Both oral propranolol alone and oral propranolol combined with topical 0.5% timolol maleate cream were proved to effectively improve the regression of IH with minor side effects. The color VAS score of oral propranolol alone group was 6.92±2.63, while the combination group was 6.88±2.33 (Z=0.043, P=0.966). The volume VAS score of oral propranolol alone group was 6.94±2.00, while the combination group was 6.98±2.11(Z=-0.051, P=0.959).@*Conclusions@#Oral propranolol combined with topical application of 0.5% timolol maleate could not increase the efficacy in the treatment of IH, compared with oral propranolol alone in the short-term observation.
ABSTRACT
Objective: To study the changes of the sensitivity of the methicillin-resistant Staphylococcus aureus (MRSA) to oxacillin after Chinese herbs. effects, so as to find Chinese medicine that can enhance the sensitivity of MRSA to antibiotics and provide new ideas for the clinical treatment of MRSA infection. Methods: A total of 33 commonly used antibacterial herbs were selected to prepare extracts, which act on clinically isolated MRSA. The broth micro dilution method was used to determine the minimal inhibitory concentration (MIC) of oxacillin on MRSA before and after the action of Chinese medicine. If there is a statistically significant difference (P ＜ 0.05), the medicine is effective. Results:The MIC of oxacillin on MRSA were 128-512 μg·ml-1, after the effect of Bletilla extracts, the change of MIC showed a statistically significant difference (P ＜ 0.05), which could increase the sensitivity of MRSA (271) to oxacillin. Conclusion:Bletilla extracts can enhance the sensitivity of MRSA (271) to oxacillin and the compatibility with antibiotics is expected to restore the efficacy of antibiotic.
ABSTRACT
Methicillin-resistant staphylococcus aureus (MRSA) has become the main pathogen for hospital and community acquired infections. Based on the resistance mechanism of MRSA, this article reviews the reducing and eliminating effect of Chinese herb extracts on bacterial drug resistance, by means of PBP2a protein binding, γ-lactamase, plasmid, efflux system, cell structure and biofilmdamage.