1.
Indian J Exp Biol
; 1997 Jul; 35(7): 765-770
Article
in English
| IMSEAR
| ID: sea-61023
ABSTRACT
HL 707, Liroldine, a novel synthetic compound, was found effective against both extraintestinal and intestinal amoebiasis in animal models. Its activity against hepatic infection in golden hamsters is comparable with that of different derivatives of nitroimidazoles used for human treatment. Against intestinal amoebiasis in Wistar rats, the activity was superior to nitroimidazoles and chloroquine. Paramomycin was comparable and diloxanide furoate was marginally superior. The comparative in vitro and in vivo studies with standard marketed drugs and Liroldine indicate an excellent profile of the compound against experimental amoebiasis. LD50 of Liroldine determined in mice is 910 mg/kg x 1, po and 940 mg/kg x 1 ip).
Subject(s)
Amebiasis/drug therapy , Amebicides/therapeutic use , Animals , Biphenyl Compounds/therapeutic use , Cricetinae , Humans , Intestinal Diseases, Parasitic/drug therapy , Liver Diseases, Parasitic/drug therapy , Mesocricetus , Mice , Microbial Sensitivity Tests , Pyrrolidines/therapeutic use , Rats , Rats, Wistar
2.
J Indian Med Assoc
; 1968 Apr; 50(8): 349-52
Article
in English
| IMSEAR
| ID: sea-104482
Subject(s)
Alkaloids/therapeutic use , Amebiasis/drug therapy , Animals , Cricetinae , Dysentery, Amebic/drug therapy , Rats
3.
J Indian Med Assoc
; 1965 Oct; 45(7): 357-62
Article
in English
| IMSEAR
| ID: sea-102181
Subject(s)
Adult , Clinical Trials as Topic , Female , Hepatitis A/drug therapy , Humans , Male , Prednisolone/therapeutic use
4.
J Indian Med Assoc
; 1964 Mar; 42(): 203-12
Article
in English
| IMSEAR
| ID: sea-104126
5.
J Indian Med Assoc
; 1964 Mar; 42(): 212-9
Article
in English
| IMSEAR
| ID: sea-102999