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Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype

Izzo, Giselle; Forlenza, Orestes V.; Santos, Bernardo dos; Bertolucci, Paulo H. F.; Ojopi, Elida B.; Gattaz, Wagner F.; Kerr, Daniel Shikanai.

Clinics ; Clinics;68(2): 277-280, 2013.

Article in English | LILACS | ID: lil-668817

ABSTRACT

In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele.

Subject(s)

Aged , Female , Humans , Male , Adaptor Proteins, Signal Transducing/genetics , Alzheimer Disease/genetics , /genetics , Cytoskeletal Proteins/genetics , LDL-Receptor Related Proteins/genetics , Membrane Transport Proteins/genetics , Nuclear Proteins/genetics , Polymorphism, Single Nucleotide/genetics , Age of Onset , Risk Factors

ABSTRACT

Subject(s)

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