ABSTRACT
We performed a retrospective epidemiologic survey on Kawasaki disease (KD) from 1997 to 1999 in Korea. We sent a questionnaire to 111 training hospitals, and summarized the data from 50 hospitals that responded. Data from a total of 3,862 cases were collected, which showed no difference in annual incidence and a seasonal predilection for summer. The male-to-female ratio was 1.51:1, and the mean age was 29.7 months. The prevalence of sibling cases was 0.26%, and the rate of recurrent cases was 2.3%. The proportion of patients with KD among total hospitalized pediatric patients was 1.19% in average, showing a significant difference according to the regions. Coronary arterial (CA) abnormalities were detected by echocardiography in 19.8% of cases (737/3,723) including dilatations in 601 cases (16.1%) and aneurysms in 191 cases (5.1%). Data from total 8,251 cases in the 1990s including the cases in the present study, in Korea showed a mean age of patients 28.9 months, male-to-female ratio 1.6:1, seasonal predilection for summer, prevalence of sibling cases 0.24%, rate of recurrent cases 2.3%, incidence of CA abnormalities 21.0%, and incidence of CA aneurysms 5.2%, with statistically significant decreasing trends in the male-to-female ratio and the rate of CA abnormalities.
Subject(s)
Adolescent , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Age Distribution , Coronary Vessels/pathology , Korea/epidemiology , Mucocutaneous Lymph Node Syndrome/epidemiology , Surveys and Questionnaires , Retrospective Studies , Seasons , Sex DistributionABSTRACT
PURPOSE: To determine the epidemiology and rate of cardiac sequelae of Kawasaki disease in Korea. METHODS: On behalf of the Korean Pediatric Cardiology Society, we sent a questionnaire to 107 training hospitals two times; first period(Jan. 94-Sep. 95) and second period(Oct. 95-Dec. 96), and summarized the data of the survey from 58 hospitals which responded. RESULTS: The total number of patients was 2,680 cases, with male to female ratio and mean age 1.6 and 28.9+/-20.0 months, respectively. The total number of cases of 19 hospitals which participated in the first and second periods was 1,045, including 354 in 1994, 315 in 1995, and 376 in 1996, which showed no difference in annual incidence and higher incidence in Jan., May, June and July. The proportions of sibling cases was 0.26%(7/2,680) and rate of recurrent cases was 1.7% (46/2,680), and the proportion of patients with Kawasaki disease among total hospitalized pediatric patients was 1.13% in average, showing no significant difference according to regions. Echocardiogram was done in 93.5% of patients(2,507/2,680), and coronary abnormalities occurred in 20.1% of cases (505/2,507) including 16.8% of dilatations and 5.4% of aneurysms. CONCLUSION: Compared with a previous study in 1991-1993, this data showed somewhat increased mean age, increased recurrence rate and decreased incidence of coronary arterial abnormalities statistically. Studies like this needs to be continued in the future to determine the epidemiologic trends of Kawasaki disease in Korea.
Subject(s)
Female , Humans , Male , Aneurysm , Cardiology , Coronary Aneurysm , Dilatation , Epidemiologic Studies , Epidemiology , Incidence , Korea , Mucocutaneous Lymph Node Syndrome , Surveys and Questionnaires , Recurrence , SiblingsABSTRACT
PURPOSE: Measles is one of the most highly communicable infectious disease, but has become a rare disease with the widespread use of vaccine. Recently, however, resurgence of the disease in school aged or adolescents who had received the vaccine before or at the 15 month warrants reappraisal of the efficacy of the vaccination. The purpose of this study was to investigate positive prevalence of antibody and its quantitative titers in different age groups in order to determine necessity and appropriate time of booster vaccine. METHODS: We measured measles antibody in the sera of 192 children from different age groups(61 cases from 4-6 years of age, 40 cases from 8-9 years of age, 47 cases from 12-13 years of age, 44 cases from 15-16 years of age). Eight to ten children from each group were selected and quantitative antibody titers were measured by EIA(measles Ig G EIA SEIKEN) method. RESULTS: 1) The positive prevalence of measles antibody in four to six year age group(72%) was significantly lower than the expected positive prevalence of measles antibody(95%) (p<0.001). 2) Median antibody titer in twelve to thirteen year age group tended to be relatively lower than the other age groups. 3) There was no significant differences in the positive prevalence of measles antibody and median titers between sex. CONCLUSIONS: This data supported that the booster vaccination be needed at four to six years of age.