ABSTRACT
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P< or =0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.
Subject(s)
Animals , Humans , Male , Rats , Administration, Topical , Aloe , Blood Vessels , Dermis , Epithelium , Fibroblasts , Glycosaminoglycans , Macrophages , Neutrophils , Rats, Wistar , Re-Epithelialization , Silver Sulfadiazine , Thyroid Gland , Thyroid Hormones , Wound HealingABSTRACT
Background: While considering the rise in the mean age of the chronic renal failure [CRF] patients and increasing frequency of those who need constant hemodialysis, the creation of a native arteriovenous fistula [AVF] is not possible, which could be due to the inaccessibility of the superficial veins. This study was conducted to evaluate the efficacy of the vascular access, using cryopreserved jugular vein
Materials and Methods: In this experimental study, 15 sheep [Wt.= 30-40 kg] were selected between the year 2001 and 2002. The external jugular vein of each sheep was excised and after cryopreservation was put in liquid nitrogen [-196°C]. Twenty-eight days later, the sample veins were used as allograft [in another sheep], and autograft [in the same sheep] and were placed between carotid artery and external jugular vein as bridge AVF. The efficacy, function, and patency were evaluated using doppler sonography and pathologic report
Results: Patency rate of sample was 100% after 3 months in both allografts and autografts. Thrombosis, hematoma, and infection were not seen. No inflammation was detected in pathologic report
Conclusion: This study showed that using allograft vein for vascular access is feasible and suitable, and it is recommended specially for those with previously infected fistula