Application of Hotelling T~2 Test in analysis of the efficacy of new drug / 中国普通外科杂志

Objective Hotelling T2 Test was used to analyze the effect of sibutramine and to provide some information for new drug's exploration. Method Fifty-five patients with body mass index (BMI) over 25kg/m2 were selected according to generally accepted including and excluding criteria. The subjects were divided into 2 groups randomly. Control group was given placebo, and the experimental group were given sibutramine. Biological and biochemical indexes were examined pre-,during and post- clinical trial. Hotelling T2 test was used to compare the index mean vector of different phases. Results There were significant statistical differences between the two groups. (P