ABSTRACT
OBJECTIVE To compare the efficacy of Danning tablet， taurosodeoxycholic acid and ursodeoxycholic acid in preventing the recurrence of choledocholithiasis after endoscopic retrograde cholangiopancreatography （ERCP）. METHODS The clinical data of 153 patients who underwent ERCP choledocholithotomy from January 2017 to January 2020 in Nantong First People’s Hospital were retrospectively analyzed. According to the different drug treatment received after surgery， patients were divided into three groups， namely， Danning tablet group （group A， 49 cases）， tauroursodeoxycholic acid group （group B， 44 cases） and ursodeoxycholic acid group （group C， 60 cases）. The above groups of drugs are all single-use， starting from 2 weeks after surgery for a course of 180 days. The effects of bile component indicators [total bilirubin （Tbil）， direct bilirubin （Dbil）， alkaline phosphatase （ALP）， glutamyltransferase （GGT）]， lipid metabolism indicators [total cholesterol （TC）， triglyceride （TG）， low-density lipoprotein （LDL）， high-density lipoprotein （HDL）]， the occurrence of clinical symptoms （abdominal pain， bloating， nausea， and poor appetite） at 6 months after ERCP， and the recurrence of choledocholithiasis at 6， 12， 18 and 24 months after surgery were compared among 3 groups. RESULTS Compared with before surgery， the serum levels of Tbil， Dbil， ALP， GGT， TC， TG and LDL were significantly reduced （P＜0.05）， while serum HDL levels were significantly increased （P＜0.05） in the three groups at 6 months after surgery. The proportion of patients who experienced abdominal pain， bloating， nausea， and poor appetite at 6 months after surgery was significantly reduced （P＜0.05）. The Tbil levels of groups A and B were significantly lower than those of group C （P＜0.05）， while the Dbil and ALP levels of group A were significantly lower than those of groups B and C （P＜0.05）； however， there was no statistically significant difference in GGT levels among the 3 groups （P＞0.05）. Compared with groups A and C， the levels of four lipid metabolism indicators in group B were significantly improved （P＜0.05）； the proportion of patients with abdominal pain， bloating， and poor appetite in group A was significantly lower than groups B and C （P＜0.05）， but there was no statistically significant difference in the proportion of patients with nausea among the 3 groups （P＞0.05）. At 6，12 and 18 months after surgery， there was no statistically significant difference in the rate of choledocholithiasis recurrence among the 3 groups （P＞0.05）； at 24 months after surgery， the rate of choledocholithiasis recurrence in group A （2.04%） was significantly lower than group B （15.91%） and group C （15.00%） （P＜0.05）. CONCLUSIONS Compared with tauroursodeoxycholic acid and ursodeoxycholic acid， the application of Danning tablet after ERCP is more beneficial to reduce the secretion of bile acid， prevent the recurrence of gallstones， and improve clinical symptoms， but tauroursodeoxycholic acid can significantly accelerate the lipid metabolism of patients compared with the other two drugs.
ABSTRACT
Objective@#To establish an autoregressive moving average model for the prediction of tuberculosis cases in students of Shanxi Province, and to provide scientific basic for the prevention and treatment of pulmonary tuerculosis among students.@*Methods@#A optimized ARIMA model was set up based on reported monthly data of TB in students from January 2010 to September 2019 in Shanxi Province by SAS 9.3 software, and the incidence trend in the next two years was predicted.@*Results@#The average reported rate of active TB in students of Shanxi Province was 23.52 per 100 000 from 2010 to 2019,showing an overall downward trend(χ2=999 980.46，P<0.01). The optimal model was SARIMA(0，1，1)(0，1，1)12,SBC=982.16. The fitted equation was (1-0.63B) (1-B12)Yt=(1-0.61B12)εt. The mean relative error was 19.35%,and the predicted incidence trend was consistent with the previous years,and the peak was from March to May.@*Conclusion@#Substantial progress has been made in student TB prevention of Shanxi Province. The ARIMA product season model is suitable for forecasting the TB incidence in students,so as to provide scientific guidance for its early prevention and control.
ABSTRACT
Blue laser imaging (BLI) is a new endoscopic system equipped with the laser beam emitting two different wavelengths.It produces bright and high resolution images for observation of microvascular and microsurface patterns of esophageal and gastric mucosa, helping the diagnosis of early upper gastrointestinal cancer.Compared with the existed endoscopic techniques, BLI shows its unique advantages.In this article, advances in application of BLI in diagnosis of early upper gastrointestinal cancer were reviewed.
ABSTRACT
[Objective] To observe the cure effect of routine massage and vibration on vertebra artery cervical spondylosis.[Method] Treat 152 cases with focal routine massage of shoulder combined with key acupoints vibration of head and abdomen for 10 times,and then observe the cure effect.[Result] 48 cases were cured,95 better,9 had no effect;the total effective rate was 94.07%.[Conclusion] The vibration can rouse and notify tri-jiao Qi,making normal rise and fall of Qi function,helpful to blood and Qi function of brain;it can increase the cure effect being combined with focal massage of shoulder.