ABSTRACT
Objective To evaluate the effects of dexmedetomidine combined with lidocaine on postopera-tive cytokine response after abdominal hysterectomy. Methods We enrolled 80 women with American Society of Anesthesiologists(ASA)physical statusⅠandⅡ,aged 35-68,and scheduled for elective abdominal hysterectomy under general anesthesia.The patients were randomly assigned into CON group,LIDO group,DEX group and LI-DO + DEX group(n=25 in each group). The four groups received an Ⅳ bolus infusion of normal saline,lido-caine,dexmedetomidine,and lidocaine combined with dexmedetomidine respectively,over 10 minutes before in-duction of anesthesia,followed by a continuous IV infusion of normal saline,lidocaine,dexmedetomidine,and li-docaine combined with dexmedetomidine until abdominal wound closure,respectively.Interleukin-6 and tumor ne-crosis factor-α levels in serum were measured before administration of drugs(T1),at the end of surgery(T2),post-operative 2 hour(T3)and postoperative 24 hour(T4). Results Interleukin-6 and tumor necrosis factor-α level in serum were higher at T2,T3and T4in the four groups. Compared to those in CON group,interleukin-6 and tumor necrosis factor-α levels in DEX and DEX+LIDO group were significantly decreased at T2,T3and T4(P<0.05). Interleukin-6 and tumor necrosis factor-α level in serum in LIDO group were also decreased at T2,T3and T4,but there was no significant difference between CON group and LIDO group(P > 0.05). Compared to that in LIDO group,tumor necrosis factor-α level in serum in DEX group was significantly decreased at T3and T4;interleukin-6 level in serum in DEX group was significantly decreased at T2,T3and T4(P<0.05).Interleukin-6 and tumor ne-crosis factor-α levels in serum in DEX+LIDO group were the lowest compared to those in other three groups at T2,T3and T4(P < 0.05). Recovery time and extubation time were significantly prolonged between DEX group and DEX + LIDO group(P < 0.05). Conclusions Dexmedetomidine combined with lidocaine infusion significantly decrease postoperative cytokine response and this may be attributed to the anti-inflammation effects of dexmedetomi-dine and lidocaine.